Korean J Ophthalmol.  2013 Apr;27(2):130-132. 10.3341/kjo.2013.27.2.130.

A Case of CMV Endotheliitis Treated with Intravitreal Ganciclovir Injection

• Choi WS
• Cho JH
• Kim HK
• Kim HS
• Shin YJ

• KMID: 1503806
• DOI: http://doi.org/10.3341/kjo.2013.27.2.130

Abstract

We report a case of CMV corneal endotheliitis that was treated with intravitreal ganciclovir injection. A 56-year-old man who has suffered from uveitis was referred to our clinic due to corneal endothelial abnormality. Slit lamp examination showed a localized sectoral corneal edema and linear keratic precipitates along the boundary of edema. In spite of treatment with oral steroid and acyclovir, the disease progressed and two new coin-like lesions were developed. After topical ganciclovir and intavitreal injection of ganciclovir, the corneal lesions disappeared.

Keyword

CMV endotheliitis; Intravitreal ganciclovir injection

MeSH Terms

Antiviral Agents/administration & dosage
Cytomegalovirus Infections/*complications/*drug therapy
Endothelium, Corneal/*virology
Ganciclovir/*administration & dosage
Humans
Intravitreal Injections
Keratitis/*drug therapy/*virology
Male
Middle Aged
Antiviral Agents
Ganciclovir

Figure

• 

  Fig. 1 Slit lamp examination showed sectorial corneal edema, keratic precipitates along the boundary of edema.

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  Fig. 2 Two new coin-like lesions pointed by arrows developed 1 week after adding oral steroids to the treatment course.

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  Fig. 3 After ganciclovir 2 mg/0.05 mL was injected into the intra-vitreous space, corneal edema almost subsided and linear keratic precipitates disappeared. The cornea returned to a normal state.

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  Fig. 4 Specular microscopy shows the reduced number of endothelial cells after treatment of linear endotheliitis.

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