Korean J Gastroenterol.  2013 May;61(5):259-264. 10.4166/kjg.2013.61.5.259.

Helicobacter pylori Seropositivity Is Positively Associated with Colorectal Neoplasms

• Nam KW
• Baeg MK
• Kwon JH
• Cho SH
• Na SJ
• Choi MG

• KMID: 1501647
• DOI: http://doi.org/10.4166/kjg.2013.61.5.259

Abstract

BACKGROUND/AIMS
Helicobacter pylori is a well known precursor to gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. This study was to determine whether H. pylori was associated with colorectal neoplasms in Korean subjects undergoing routine checkup.
METHODS
A total of 10,082 subjects underwent routine checkups from January 2004 to April 2005. A H. pylori IgG test and stool occult blood test were included in the routine checkup program. Colonoscopy was performed if the stool occult blood test was positive or under subject request. Patients who underwent colonoscopy and had histologically confirmed cases of colorectal neoplasms were designanted as the subject group and those without as the control group.
RESULTS
Of the 10,082 subjects, 597 had full colonoscopy. The results identified 9 colorectal carcinomas and 118 adenomas. H. pylori seropositivity was identified in 6 (66%) subjects with colorectal carcinoma, 81 (68.6%) with colorectal adenoma and 248 (52.8%) controls. Subjects having colorectal neoplasms had a significantly higher H. pylori seropositivity rate compared with the controls (OR 1.94, 95% CI 1.28-2.95). This remained significant after adjusting for age, sex, body mass index, HbA1c and total cholesterol (OR 1.90, 95% CI 1.23-2.93). Patients with distal neoplasms also had a significantly higher H. pylori seroposivity rate (OR 1.88, 95% CI 1.17-3.01) which persisted after multivariate adjustment (OR 1.79, 95% CI 1.10-2.94).
CONCLUSIONS
Subjects with colorectal neoplasms present an increased H. pylori seroprevalence compared with controls.

Keyword

Helicobacter pylori; Colorectal neoplasms; Colonoscopy

MeSH Terms

Adenoma/*diagnosis/etiology
Adult
Age Factors
Aged
Body Mass Index
Cholesterol/blood
Colonoscopy
Colorectal Neoplasms/*diagnosis/epidemiology/etiology
Female
Helicobacter Infections/complications/*diagnosis
Helicobacter pylori/*immunology
Hemoglobin A, Glycosylated/analysis
Humans
Immunoglobulin G/analysis
Male
Middle Aged
Occult Blood
Odds Ratio
Retrospective Studies
Risk Factors
Sex Factors
Cholesterol
Hemoglobin A, Glycosylated
Immunoglobulin G

Reference

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