Korean J Thorac Cardiovasc Surg.
2008 Apr;41(2):223-228.
Serum Lmmunoglobulin G and M Level after Xenograft Valve or Valved Conduit Implantation
- Affiliations
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- 1Department of Thoracic and Cardiovascular Surgery, College of Medicine, Seoul National University, Seoul National University Hospital, Korea. kyj@plaza.snu.ac.kr
- 2Seoul National University Hospital, College of Medicine, Xenotransplantation Research Center, Korea.
Abstract
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BACKGROUND: The aim of this study is to confirm that peripheral blood sampling for measuring of serum immunoglobulin can predict immunological changes after xenograft implantation.
MATERIAL AND METHOD: Between March 2006 and January 2007, 19 patients were enrolled (10 xenograft implantation group, 9 control group). Through 3 peripheral blood samples, we measured changes in serum immunoglobulin G and M levels preoperatively, and 2 and 10 days postoperatively.
RESULT: In both groups, serum immunoglobulin levels showed similar changes-they decreased 2 days postoperatively, then increased up to the baseline levels 10 days postoperatively. However, this postoperative change of immunoglobulin G and M was not significantly different in absolute value or pattern between the 2 groups (Ig G; p-value=0.393, Ig M; p-value=0.193).
CONCLUSION
We could not predict immunological changes after xenograft implantation by measuring serum immunoglobulin levels by simple blood sampling. Direct checking of alpha-Galactose antibody may confirm an immunological reaction after xenograft implantation.
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