Korean J Med.
2009 Mar;76(3):365-369.
Allopurinol-induced agranulocytosis in a patient on peritoneal dialysis
- Affiliations
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- 1Hallym Kidney Research Institute, College of Medicine, Hallym University, Seoul, Korea. km2071@unitel.co.kr
- 2Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea.
- 3Department of Laboratory Medicine, College of Medicine, Hallym University, Seoul, Korea.
Abstract
- Agranulocytosis is a rare, but sometimes dangerous, adverse reaction to allopurinol. We report the unusual case of a 43-year-old man with agranulocytosis, who received allopurinol while undergoing peritoneal dialysis. The bone marrow biopsy indicated that the agranulocytosis was drug-induced. After ceasing all drugs, isolating the patient, and administering granulocyte colony-stimulating factor (G-CSF), the leukocyte count returned to normal. A relationship between allopurinol therapy and agranulocytosis was presumed.
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