Korean J Hematol.  2008 Dec;43(4):276-279. 10.5045/kjh.2008.43.4.276.

A Case of Primary NK/T Cell Lymphoma of the Testis

• Park J
• Lee W
• Kim M
• Lee HW
• Kim BW
• Choi YJ
• Shin HJ
• Chang JS
• Cho GJ

• KMID: 1485089
• DOI: http://doi.org/10.5045/kjh.2008.43.4.276

Abstract

Primary testicular lymphoma account for 1~5% of all testicular neoplasms. The majority of these tumors are diffuse large B-cell non-Hodgkin lymphoma. Primary NK/T cell lymphoma of the testis is a rare entity. Regardless of treatment, the majority of these patients have exhibited a highly aggressive clinical course and they have died within 1 year because of early dissemination. We report here on a case of the aggressive 'nasal type' natural killer (NK)/T cell lymphoma that initially presented as a testicular tumor. A 63-year-old man presented with painless left testicular swelling, and so a left orchiectomy was performed. A biopsy specimen of the testis revealed an extranodal NK/T cell lymphoma of the nasal type. In-situ hybridization for Epstein-Barr virus proved positive. The patient received systemic chemotherapy with 3 courses of a combination regimen.

Keyword

NK/T cell lymphoma; Testicular lymphoma; Testis

MeSH Terms

B-Lymphocytes
Biopsy
Chimera
Herpesvirus 4, Human
Humans
Lymphoma
Lymphoma, Non-Hodgkin
Middle Aged
Orchiectomy
Testicular Neoplasms
Testis

Figure

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  Fig. 1 Postoperative abdominal CT scan finding. (A) The jejunum shows multifocal wall thickening(arrow). (B) Multiple mesenteric lymph nodes are noted.

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  Fig. 2 Microscopic findings of testicular mass showing a diffuse dense infiltration of atypical medium sized lymphoid cells with high mitotic rate accompanied by angio-centric infiltration (H&E statin, ×400).

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  Fig. 3 Immunohistochemical staining shows (A) CD3+ (×400), and (B) CD56+ (×400).

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