Clin Pediatr Hematol Oncol.  2008 Apr;15(1):27-32.

Primary Signet-Ring Cell Carcinoma of the Colon in a Child

Affiliations
  • 1Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. pedkjs@uuh.ulsan.kr
  • 2Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
  • 3Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Abstract

Primary signet-ring cell carcinoma (SRCC) is one of extremely rare colorectal diseases in children. It has frequently metastasized to other sites of the body and presented with worse prognosis. We report a case of primary SRCC of the descending colon in a 14-year-old girl who presented with lower abdominal pain and vomiting. The diagnosis of SRCC with peritoneal seeding was made with abdominal CT scan and colonoscopic biopsy. We performed the left hemicolectomy and administered the intense chemotherapy regimens for SRCC, and then the patient's disease status had been stable for 14 months. However, her clinical course had deteriorated in spite of the multimodal chemotherapy regimens. She died of multiple metastasis 24 months after the initial diagnosis of SRCC. Since the prognosis of primary SRCC of the colon is extremely poor, early diagnosis and aggressive treatment strategies are needed.

Keyword

Signet-ring cell carcinoma; Colon cancer; Child

MeSH Terms

Abdominal Pain
Adolescent
Biopsy
Child
Colon
Colon, Descending
Colonic Neoplasms
Early Diagnosis
Humans
Neoplasm Metastasis
Prognosis
Seeds
Vomiting
Full Text Links
  • CPHO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr