Korean J Obstet Gynecol.
2008 Aug;51(8):850-857.
Epithelial ovarian cancer in patients under 20 years of age
- Affiliations
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- 1Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea. leejm@catholic.ac.kr
- 2Kangnam St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
- 3Seoul Medical Center, Holy Family Hospital, The Catholic University of Korea, Seoul, Korea.
Abstract
OBJECTIVE
Epithelial ovarian cancer is the most common cause of death due to gynecologic malignancies in adults, but is rare in children and adolescents. This is a report of series of such patients under 20 years of age documenting their presentation, histologic type, stage of disease, treatment, and outcome.
METHODS
We collected data on 21 patients with epithelial ovarian cancer under 20 years of age between January 1990 and December 2005. Patient records and pathology were reviewed.
RESULTS
Epithelial ovarian cancer under 20 years of age was 2.2% in overall ovarian cancer. Epithelial ovarian cancer was 42.0% among 50 patients under 20 years of age and the most common histologic type was germ cell tumors (54%). The median age at the time of diagnosis was 17.6 years (range, 13-20 years), and the median follow-up was 87 months (range, 4-175 months). There were seventeen (81.0%) mucinous tumors, four (19.0%) serous tumors. About thirty-eight percent were low malignant potential or borderline tumors. About Eighty-five percent (18 patients) of tumors were stage I disease and about fourteen percent (3 patients) were stage III disease at the time of diagnosis. Surgical treatment included conservative surgery in 18 patients (85.7%), total abdominal hysterectomy and bilateral salpingo- oophorectomy in 3 patients (14.3%).
CONCLUSION
Epithelial ovarian cancers are rare in patients in children and adolescents. The majority of ovarian cancers in this age group are mucinous tumors, stage I at diagnosis and borderline ovarian tumor. Conservative management is feasible to achieve preservation of fertility.
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