J Korean Endocr Soc.  2008 Oct;23(5):352-357. 10.3803/jkes.2008.23.5.352.

Primary Hypogonadism Associated with Ankylosing Spondylitis

Affiliations
  • 1Division of Endocrinology, Department of Internal Medicine, The Catholic University of Korea, Korea.

Abstract

Male patients with hypogonadism have an increased risk of developing rheumatic diseases. Most causes of hypogonadism related with rheumatic disease are karyotype abnormality such as Klinefelter's syndrome or Turner's syndrome and gonadal dysgenesis. A 24-year-old year male was admitted for pain of both hip joints that had worsened over 2 months. He had hip joint involvement from ankylosing spondylitis and did not show secondary sex characteristics. His sex hormones and gonadotropins levels indicated hypergonadotropic hypogonadism. The karyotype was 46 XY, and there was no obvious cause of hypogonadism. Here we report on clinical features of this first Korean case of primary hypogonadism accompanying ankylosing spondylitis.

Keyword

ankylosing spondylitis; hypergonadotropic hypogonadism; rheumatic disease

MeSH Terms

Gonadal Dysgenesis
Gonadal Steroid Hormones
Gonadotropins
Hip Joint
Humans
Hypogonadism
Karyotype
Klinefelter Syndrome
Male
Rheumatic Diseases
Sex Characteristics
Spondylitis, Ankylosing
Turner Syndrome
Young Adult
Gonadal Steroid Hormones
Gonadotropins

Figure

  • Fig. 1 Clinical feature of the patient. He showed obese build and gynecomastia, axillary hair loss, genu valgum and he had a small penis and scrotums.

  • Fig. 2 X-ray test of hip joint. Marginal erosive change with sclerosis at acetabular side of both hip joint is noted with mild space narrowing.

  • Fig. 3 T2-weighted magnetic resonance images through the sacroiliac joints. Arrows showed enhancement at the both sacroiliac joints, indicating active sacroiliitis.

  • Fig. 4 Sonography of testes. Too small testes are noted (Lt. 1.3 × 0.5 cm, Rt. 1.5 × 0.5 cm) and subcutaneous fat is very thick.


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