Korean J Blood Transfus.  2008 Apr;19(1):57-62.

A Case of Anti-Yka Antibody as an High-Titer, Low-Avidity Antibody: The First Case in Korea

• Yoon S
• Lim YA

Abstract

Authors found a case of anti-Yka antibody in a 66-year-old female patient with acute peritonitis due to colon cancer perforation. Although anti-Yka antibody has no clinical significance, its high-titer, low-avidity (HTLA) characteristics with weak and variable reactivity to Yk(a+) RBC in the indirect antiglobulin test can cause confusion and difficulties in identifying coexisting clinically significant antibodies. Titration studies could be used to determine such reactions due to HTLA antibodies. Since anti-Yka antibody has not been shown to cause significant destruction of transfused Yk(a+) RBC, Yk(a+) units can be safely transfused to patients with anti-Yka antibody unless clinically significant antibodies coexist in their sera. This is the first case report of anti-Yka antibody as an high-titer, low-avidity antibody in Korea.

Keyword

Anti-Yka antibody; HTLA; Blood transfusion

MeSH Terms

Aged
Antibodies
Blood Transfusion
Colonic Neoplasms
Coombs Test
Female
Humans
Korea
Peritonitis
Antibodies