Korean J Pathol.  2009 Feb;43(1):20-25. 10.4132/KoreanJPathol.2009.43.1.20.

Metaplastic Squamous Carcinoma of the Breast: Clinicopathologic Analysis of 17 Cases

• Lee SA
• Lee KE
• Moon BI
• Han WS
• Sung SH

• KMID: 1472550
• DOI: http://doi.org/10.4132/KoreanJPathol.2009.43.1.20

Abstract

BACKGROUND
Squamous cell carcinoma of the breast is very rare and it is considered to arise from metaplastic change of ductal carcinoma. Metaplastic squamous cell carcinoma (MSC) of the breast includes pure squamous cell carcinoma, metaplastic adenosquamous carcinoma and low grade adenosquamous carcinoma. Most of the cases of MSC of the breast were reported to have lymph node metastasis and this has a worse prognosis than that of conventional invasive ductal carcinoma.
METHODS
We collected 17 cases of MSC of the breast from 1,173 cases of breast cancer and analyzed the clinicopathological characteristics.
RESULTS
The age range was 31 to 69 years (mean age: 47.2). The mean tumor size was 3.6 cm. Twelve cases (70.6%) had a negative nodal status. The majority of the cases were of a high nuclear grade (grade III: 76.5%), and a high histologic grade (grade III: 88.2%). All the cases had no amplification of HER2, and they were negative for hormonal receptors, except for 2 cases with weak positivity. All the cases showed positivity for EGFR (3+: 14 cases, 1+: 3 cases). Clinical relapse was found in 3 patients on follow up and two of them expired due to lung and bone metastasis.
CONCLUSIONS
MSC is associated with high nuclear and histologic grades, a high EGFR expression and they are triple negative for ER, PR, and HER2. The EGFR immunopositivity of MSC suggests a basal-like subtype.

Keyword

Breast cancer; Squamous cell carcinoma; Epidermal growth factor receptor; TP63 protein, human

MeSH Terms

Breast
Breast Neoplasms
Carcinoma, Adenosquamous
Carcinoma, Ductal
Carcinoma, Squamous Cell
Follow-Up Studies
Humans
Lung
Lymph Nodes
Neoplasm Metastasis
Prognosis
Receptor, Epidermal Growth Factor
Recurrence
Transcription Factors
Tumor Suppressor Proteins
Receptor, Epidermal Growth Factor
Transcription Factors
Tumor Suppressor Proteins