Korean J Nephrol.  2009 May;28(3):243-247.

A Case of Anti-Glomerular Basement Membrane Disease Improved by Early Plasmapheresis and Immunosuppression Therapy

• Kim JH
• You SJ
• Park JS
• Lee CH
• Kim GH
• Kang CM
• Lim SD
• Lee JH

Abstract

Anti-glomerular basement membrane disease is a rare autoimmune disease characterized by rapidly progressive renal failure and/or pulmonary hemorrhage. The presence of severe crescentic glomerular inflammation with linear deposition of immunoglobulin G along the glomerular basement membrane is pathognomonic. Because renal function is rapidly and often irretrievably destroyed, many patients require hemodialysis all through their lifetime. We report a case of 33 year(s)-old man who was diagnosed as anti-glomerular basement membrane disease without pulmonary hemorrhage. The patient was treated with pulse methylprednisolone and plasmapheresis followed by oral corticosteroid and cyclophosphamide. His renal function was successfully recovered with early diagnosis and aggressive treatment.

Keyword

Anti-glomerular basement membrane disease; Corticosteroids; Plasmapheresis; Cyclophosphamide

MeSH Terms

Adrenal Cortex Hormones
Anti-Glomerular Basement Membrane Disease
Autoimmune Diseases
Cyclophosphamide
Early Diagnosis
Glomerular Basement Membrane
Hemorrhage
Humans
Immunoglobulin G
Immunosuppression
Inflammation
Methylprednisolone
Plasmapheresis
Renal Dialysis
Renal Insufficiency
Adrenal Cortex Hormones
Cyclophosphamide
Immunoglobulin G
Methylprednisolone