Hanyang Med Rev.  2010 Aug;30(3):156-175. 10.7599/hmr.2010.30.3.156.

International Travel and Imported Parasitic Diseases

• Joo KH

• KMID: 1460251
• DOI: http://doi.org/10.7599/hmr.2010.30.3.156

Abstract

International travel has become increasingly common as travelers of various purposes. It is estimated that there are 900 million international tourist arrivals alone each year. Unfortunately, some health impairments were reported in about 50% of short term travelers to the tropics or sub-tropics, usually due to infectious agents. In this paper, the author reviewed imported parasitic diseases in Korea from 1970 to 2009 with literature and data collected by Korea Centers for Disease Control and Prevention (KCDC). The author also reviewed warning points about parasitic disease in pregnant and immune deficit travelers. Most prevalent imported parasitic disease was malaria. About 30~70 travelers infected with malaria are returned home anually from abroad, mostly South East Asia and Africa. Subtype of malaria classified from 2003~2006 surveillance data showed Plasmodium falciparum infection in about 55% of patients identified. Over 20 cases of hydatid disease and cutaneous leishmaniasis cases were reported respectively. Visceral leishmaniasis (5 cases), babesiosis (7 cases), loiasis (3 cases), cutaneous myiasis (1 case), pentastomiasis (1 case), gnathostomiasis (4 cases, 41 people), angiostrongylosis (1 case, 10 people), heterophyiasis (2 cases), schistosomiasis (13 cases), cyclosporiasis (1 case), cutaneous larva migrans (4 cases), ancylostomiasis (1 case) and syngamosis (1 case) were reported. Prevention and surveillance plan of imported parasitic diseases is organized and conducted by KCDC since 2001. According to increasing travel to developing or under developed countries, retraining of doctor and technician, systematization of consulting system for diagnosis of parasitic disease, supply of medication, supplement of the personnel, and financial supports are needed.

Keyword

Imported Parasite; Malaria; Infection; Travel

MeSH Terms

Africa
Ancylostomiasis
Animals
Babesiosis
Centers for Disease Control and Prevention (U.S.)
Cyclosporiasis
Developing Countries
Far East
Financial Support
Gnathostomiasis
Humans
Korea
Larva Migrans
Leishmaniasis, Cutaneous
Leishmaniasis, Visceral
Loiasis
Malaria
Myiasis
Parasitic Diseases
Plasmodium falciparum
Schistosomiasis

Reference

1. World Tourism Organization. Facts and Figures. 2009. Madrid: World Tourism Organization;(www.worldtourism.org).

2. Steffen R, deBernardis C, Banos A. Travel epidemiology-A global perspective. Int J Antimicrob Agents. 2003. 21:89–95.

3. Steffen R, Rickenbach M, Wilhelm U, Helminger A, Schar M. Health problems after travel to developing countries. J Infect Dis. 1987. 156:84–91.

4. Cossar JH, Reid D, Fallon RJ, Bell EJ, Riding MH, Follett EA, Dow BC, Mitchell S, Grist NR. A cumulative review of studies on travellers, their experience of illness and the implications of these findings. J Infect. 1990. 21:27–42.

5. Hargarten SW, Baker TD, Guptill K. Overseas fatalities of Unites States citizen travelers: An analysis of deaths related to international travelers. Ann Emerg Med. 1991. 20:622–626.

6. Sniezek JE, Smith SM. Injury mortality among non-U.S. residents in the Unites States 1979-1984. Int J Epidemiol. 1991. 20:225–229.

7. Guptill KS, Hargarten SW, Baker TD. American travel deaths in Mexico: Causes and prevention strategies. West J Med. 1991. 154:169–171.

8. Paixao ML, Dewar RD, Cossar JH, Covell RG, Reid D. What do Scots die of when abroad? Scott Med J. 1991. 36:114–116.

9. Prociv P. Deaths of Australian travelers overseas. Med J Aust. 1995. 163:27–30.

10. Valdez LM, Gotuzzo E, Thielman NM, Dupont HL. Guerrant RL, Walker DH, Weller PF, editors. Gastrointestinal symptoms. Tropical Infectious Diseases. 2006. 2nd ed. Philadelphia, USA: Elsevier;1446–1458.

11. Schlagenhauf P, Meuntner P. Schlagenhauf P, editor. Imported malaria. Traveler's malaria. 2001. Hamilton, Ontario, Canada: BC Decker;495–508.

12. Korea Centers for Disease Control and Prevention (2001-2009).

13. Trampuz A, Jereb M, Muzlovic I, Prabhu R. Clinical review: Severe malaria. Crit Care. 2003. 7:315–323.

14. Cox F. History of human parasitology. Clin Microbiol Rev. 2002. 15:595–612.

15. Soh CT, Lee KT, Im KI, Min DY, Ahn MH, Kim JJ, Yong TS. Current status of malaria in Korea. Yonsei Rep Trop Med. 1985. 16:11–18.

16. Korea Centers for Disease Control and Prevention (KCDC). Malaria management principles 2010.

17. Lee SW. Recent trend of the imported infectious diseases in Korea. 2006. In : Federation meeting of the Korean Society of Travel Medicine; 43–49. (in Korean).

18. Song HS, Kim JY, Na DJ, Kim JY, Kim YJ, Yeom JS, Yoon HJ. The first case of Plasmodium malariae infection imported from Nigeria to Korea. Korean J Med. 2009. 77:Supple 5. 1323–1327.

19. Kim JY, Kim JS, Park MH, Kang YA, Kwon JW, Cho SH, Lee BC, Kim TS, Lee JK. A locally acquired falciparum malaria via nosocomial transmission in Korea. Korean J Parasitol. 2009. 47:269–273.

20. Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S. Cutaneous leishmaniasis. Lancet Infect Dis. 2007. 7:581–596.

21. Vannier-Santos MA, Martiny A, de Souza W. Cell biology of Leishmania spp: Invading and evading. Curr Pharm Des. 2002. 8:297–318.

22. Yadon ZE, Rodrigues LC, Davies CR, Quigley MA. Indoor and peridomestic transmission of American cutaneous leishmaniasis in northwestern Argentina: A retrospective case-control study. Am J Trop Med Hyg. 2003. 68:519–526.

23. Marsden PD. Mucosal leishmaniasis ("espundia" Escomel, 1911). Trans R Soc Trop Med Hyg. 1986. 80:859–876.

24. Kim DY, Cho SB, Chung KY. A case of cutaneous leishmaniasis treated with intralesional injection of meglumine antimoniate. Korean J Dermatol. 2006. 44:113–116.

25. Yoo TY, Chang BK, Lee SH. Two cases of cutaneous leishmaniasis. Korean J Dermatol. 1978. 16:477–486.

26. Kim HJ, Shin DH, Kim YW. Five cases of cutaneous leishmaniasis. Korean J Dermatol. 1984. 22:60–67.

27. Yun TY, Eun HC, Lee YS, Chi JG, Ham EK, Hong ST, Lee SH. Two cases of imported cutaneous leishmaniasis in Korea. Korean J Parasitol. 1985. 23:327–330.

28. Park BC, Chae HJ, Yi JY, Cho BK, Houh W, Kim DJ, Choi WY. Two cases of cutaneous leishmaniasis treated with itraconazole. Ann Dermatol. 1992. 4:91–94.

29. Park JS, Lee DK, Hong SJ, Son SJ, Cho MK. A case of cutaneous leishmaniasis. Korean J Dermatol. 2001. 39:725–727.

30. Kim YJ, Hwang ES, Yoo DS, Son SW, Uhm CS, Kim IH. A case of localized cutaneous leishmaniasis in a native Korean. Korean J Dermatol. 2004. 42:884–888.

31. James WD, Berger T, Elston DM. Andrews' Diseases of the Skin: clinical Dermatology. 2006. 10th ed. Michigan, USA: Saunders Elsevier.

32. Berger RS, Perez-Figaredo RA, Spielvogel RL. Leishmaniasis: The touch preparation as a rapid means of diagnosis. J Am Acad Dermatol. 1987. 16:1096–1105.

33. Hockmeyer WT, Kager PA, Rees PH, Hendricks LD. The culture of Leishmania donovani in Schneider's insect medium: Its value in the diagnosis and management of patients with visceral leishmaniasis. Trans R Soc Trop Med Hyg. 1981. 75:861–863.

34. Herwaldt BL, Berman JD. Recommendations for treating leishmaniasis with sodium stibogluconate (Pentostam) and review of pertinent clinical studies. Am J Trop Med Hyg. 1992. 46:296–306.

35. Croft SL, Davidson RN, Thornton EA. Liposomal amphotericin B in the treatment of visceral leishmaniasis. J Antimicrob Chemother. 1991. 28:Suppl B. 111–118.

36. Torre-Cisneros J, Villanueva JL, Kindelan JM, Jurado R, Sanchez-Guijo P. Successful treatment of antimony-resistant visceral leishmaniasis with liposomal amphotericin B in patients infected with human immunodeficiency virus. Clin Infect Dis. 1993. 17:625–627.

37. Jha TK, Sundar S, Thakur CP, Bachmann P, Karbwang J, Fischer C, Voss A, Berman J. Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis. N Engl J Med. 1999. 341:1795–1800.

38. Sundar S, Makharia A, More DK, Agrawal G, Voss A, Fischer C, Bachmann P, Murray HW. Short-course oral miltefosine for treatment of visceral leishmaniasis. Clin Infect Dis. 2000. 31:1110–1113.

39. Heu IM. Three cases of Kala-azar, especially on the various serologic reaction. Korean J Intern Med. 1949. 1:118–121.

40. Chi JG, Shong YK, Hong ST, Lee SH, Seo BS, Choe KW. An imported case of Kala-azar in Korea. Korean J Parasitol. 1983. 21:87–94.

41. Kim HY, Jung SE, Park KW, Kim WK. Visceral leishmaniasis in a child. J Korean Assoc Pediatr Surg. 2004. 10:35–38.

42. Herwaldt B, Persing DH, Précigout EA, Goff WL, Mathiesen DA, Taylor PW, Eberhard ML, Gorenflot AF. A fatal case of babesiosis in Missouri: Identification of another piroplasm that infect humans. Ann of Intern Med. 1996. 124:643–650.

43. Hunfeld KP, Hildebrandt A, Gray JS. Babesiosis: Recent insights into an ancient disease. Int J Parasitol. 2008. 38:1219–1237.

44. Setty S, Khalil Z, Schori P, Azar M, Ferrieri P. Babesiosis. Two atypical cases from Minnesota and a review. Am J Clin Pathol. 2003. 120:554–559.

45. Kim HT, Song YW, Choe KW, Chai JY, Lee SH. An imported case of human babesiosis in Korea. Korean J Intern Med. 1988. 35:569–573.

46. Sim JG, Park HS, Ahn DH, Kho WG, Chai JY. A case of babesiosis in an eight year old Korean boy. J Korean Pediatr Soc. 1991. 34:1417–1421.

47. Lee SS, Yang SY, Cho YK, Kim E, Kim YS, Woo JH, Ryu J, Chai JY. An imported case of babesiosis. Korean J Infect Dis. 1997. 29:49–52.

48. Kweon SH, Kim YS, Pai H, Park J, Park H, Choi HH, Chai JY. A case of mixed infection with malaria and Babesia. Korean J Infect Dis. 1998. 30:198–202.

49. Yoon KT, Kim YA, Ku NS, Kim JH, Jung SJ, Kim HJ, Song KH, Choi YK, Shin SY, Kim YK, Kim MS, Park YS, Choi JY, Sung YG, Kim JM. A case of human babesiosis confirmed by polymerase chain reaction and treated with Atovaquone and Azithromycin. Infect Chemother. 2006. 38:300–303.

50. Jang HJ, Kim JH, Park WJ, Kim CH, Kim DG, Hyun IG, Huh S, Kho WG, Chai JY. A case of intraerythrocytic parasitism treated with Quinine and Clindamycin. Korean J Infect Dis. 1998. 30:478–482.

51. Kim JY, Cho Sh, Joo HN, Tsuji M, Cho SR, Park IJ, Chung GT, JU JW, Cheun HI, Lee HW, Lee YH, Kim TS. First case of human babesiosis in Korea: Detection and characterization of a novel type of Babesia sp. (Ko1) similar to ovine Babesia. J Clin Microbiol. 2007. 45:2084–2087.

52. Stoll R. This wormy world. 1947. J Parasitol. 1999. 85:392–396.

53. Nutman TB, Miller KD, Mulligan M, Ottesen EA. Loa loa infection in temporary residents of endemic regions: Recognition of a hyperresponsive syndrome with characteristic clinical manifestations. J Infect Dis. 1986. 154:10–18.

54. Klion AD, Massougbodji A, Sadeler BC, Ottesen EA, Nutman TB. Loiasis in endemic and non-endemic populations: Immunologically mediated differences in clinical presentation. J Infect Dis. 1991. 163:1318–1325.

55. Drugs for parasitic infections. Med Lett. 2002. 1:3–4.

56. Ten Berg JAG. Filariasis Loa; Treatment with Hetrazan. Doc Med Geogr Trop. 1952. 4:209–218.

57. Van Dellen RG, Ottesen EA, Gocke TM, Neafie RC. Loa loa. An unusual case of chronic urticaria and angioedema in the United States. JAMA. 1985. 253:1924–1925.

58. Min DY, Soh CT, Woon JW. A case of Calabar swelling suspected a loiasis. Korean J Parasitol. 1987. 25:185–187.

59. Chun YS, Chun SI, Im KI, Moon TK, Lee MG. A case of loiasis. Yonsei Med J. 1998. 39:184–188.

60. Cho HY, Lee YJ, Shin SY, Song HO, Ahn MH, Ryu JS. Subconjunctival Loa loa with Calabar swelling. J Korean Med Sci. 2008. 23:731–733.

61. Kim YK, Kim HJ, Hwang KJ, Ree HI. Cutaneous myiasis by Cordylobia anthropophagi. J Korean Med Assoc. 1990. 33:443–446.

62. Drabick JJ. Pentastomiasis. Rev Infect Dis. 1987. 9:1087–1094.

63. Binford CH, Conner DH. Pathology of Tropical and Extraordinary Diseases. 1976. Vol 2. Washington DC, USA: Armed Forces Institute of Pathology.

64. Park CS, Kim MW, Hong WK, Lee HB, Kang DY, Chai JY, Lee SH. Pentastomiasis which caused eosinohilic pneumonia: Report of a case. J Korean Med Assoc. 1985. 28:1141–1146.

65. John DT, Petr WA. Markell and Voge's Medical Parasitology. 2006. 9th ed. Philadelphia, USA: Elsevier Inc.

66. Almeyda-Artigas RJ, Bargues MD, Mas-Coma S. ITS-2 rDNA sequencing of Gnathostoma species (Nematoda) and elucidation of the species causing human gnathostomiasis in the Americas. J Parasitol. 2000. 86:537–544.

67. Leon-Regagnon V, Osorio-Sarabia D, Garcia-Prieto L, Akahane H, Lamothe-Argumedo R, Koga M, Messina-Robles M, Alvarez-Guerrero C. Study of the ethiological agent of gnathostomosis in Nayarit, Mexico. Parasitol Int. 2002. 51:201–204.

68. Gutierrez Y. Diagnostic Pathology of Parasitic Infections with Clinical Correlations. 2000. New York, USA: Oxford University Press;769.

69. Daengsvang S. Gnathostomiasis in Southeast Asia. Southeast Asian J Trop Med Public Health. 1981. 12:319–332.

70. Barua P, Hazarika NK, Barua N, Barua CK, Choudhury B. Gnathostomiasis of the anterior chamber. Indian J Med Microbiol. 2007. 25:276–278.

71. Boongird P, Phuapradit P, Siridej N, Chirachariyavej T, Chuahirun S, Vejjajiva A. Neurological manifestations of gnathostomiasis. J Neurol Sci. 1977. 31:279–291.

72. Lee SH, Hong ST, Chai JY. Description of male Gnathostoma spinigerum recovered from a Thai woman with meningoencephalitis. Korean J Parasitol. 1988. 26:33–38.

73. Lee SD, Lee HJ, Kim JW. A case of gnathostomiasis. Korean J Dermatol. 2001. 39:1427–1429.

74. Chai JY, Han ET, Shin EH, Park JH, Chu JP, Hirota M, Nakamura-Uchiyama F, Nawa Y. An outbreak of gnathostomiasis among Korean emigrants in Myanmar. Am J Trop Med Hyg. 2003. 69:67–73.

75. Bae EY, Koh BK, Kim JW. A case of human gnathostomiasis successfully treated with ivermectin. Ann Dermatol. 2006. 18:33–36.

76. Kliks MM, Palumbo NE. Eosinophilic meningitis beyond the Pacific Basin: The global dispersal of a peridomestic zoonosis caused by Angiostrongylus cantonensis, the nematode lungworm of rats. Soc Sci Med. 1992. 34:199–212.

77. Punyagupta S, Juttijudata P, Bunnag T. Eosinophilic meningitis in Thailand. Clinical studies of 484 typical cases probably caused by Angiostrongylus cantonensis. Am J Trop Med Hyg. 1975. 24:921–931.

78. Kuberski T, Wallace GD. Clinical manifestations of eosinophilic meningitis due to Angiostrongylus cantonensis. Neurology. 1979. 29:1566–1570.

79. Yii CY. Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. Am J Trop Med Hyg. 1976. 25:233–249.

80. Koo J, Pien F, Kliks MM. Angiostrongylus (Parastrongylus) eosinophilic meningitis. Rev Infect Dis. 1988. 10:1155–1162.

81. Bowden DK. Eosinophilic meningitis in the New Hebrides: Two outbreaks and two deaths. Am J Trop Med Hyg. 1981. 30:1141–1143.

82. Kliks MM, Kroenke K, Hardman JM. Eosinophilic radiculomyeloencephalitis: An angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snils. Am J Trop Med Hyg. 1982. 31:1114–1122.

83. Chai JY, Seo BS, Lee SH, Hong SJ, Sohn WM. Human infection by Heterophyes heterophyes and H. dispar imported from Saudi Arabia. Korean J Parasitol. 1986. 24:82–86.

84. Cho SY, Kang SY, Lee JB. Metagonimiasis in Korea. Arzneimittelforschung. 1984. 34:1121–1123.

85. Sheir ZM, Aboul-Enein ME. Demographic, clinical and therapeutic appraisal of heterophyiasis. J Trop Med Hyg. 1970. 73:148–152.

86. Tantachamrun T, Kliks M. Heterophyid infection in human ileum: report of three cases. Southeast Asian J Trop Med Public Health. 1978. 9:228–231.

87. WHO Technical Report Series No 849. Report of a WHO Study Group. Control of Foodborne Trematode Infections. 1995. Geneva: World Health Organization.

88. Bunnag D, Radomyos P, Harinasuta T. Field trial on the treatment of fasciolopsiasis with praziquantel. Southeast Asian J Trop Med Public Health. 1983. 14:216–219.

89. Chitsulo L, Engels D, Montresor A, Savioli L. The global status of schistosomiasis and its control. Acta Trop. 2000. 77:41–51.

90. Arap Siongok TK, Mahmoud AA, Ouma JH, Warren KS, Muller AS, Handa AK, Houser HB. Morbidity in schistosomiasis mansoni in relation to intensity of infection: Study of a community in Machakos. Kenya. Am J Trop Med Hyg. 1976. 25:273–284.

91. Min DY, Soh CT, Lee MS, Choi HK, Park CI. Urinary schistosomiasis among Korean returnees from the Middle-East. Yonsei Rep Trop Med. 1982. 13:36–40.

92. Lee SY, Lee HC, Park YY, Kwon SW, Kim OK. Urinary schistosomiasis: A case report. Korean J Urol. 1989. 30:224–227.

93. Kim YD, Choi SK, KIm BT, Shin WH, Byun BJ. Cerebellar schistosomiasis. Case report. J Korean Neurosurg Soc. 1994. 23:1096–1100.

94. Lee YK, Choi TY, Jin SY, Lee DW. Imported CNS schistosomiasis. A case report. J Korean Med Sci. 1995. 10:57–61.

95. Lim SD, Suh YL, Chi JG, Hong ST, Lee SH. Mansonian schistosomiasis in rectum. Korean J Parasitol. 1995. 33:383–386.

96. Hong CK, Yang JM, Kang BK, Kim JD, Kim YC, Chang UI, Yoo JY. A Case of Combined Hepatocellular-Cholangiocarcinoma with Underlying Schistosomiasis. Korean J Intern Med. 2007. 22:283–286.

97. Kim JK, Hong SH, Lee JK. High-Level Cervical Spinal Cord Stimulation Used to Treat Intractable Pain Arising from Transverse Myelitis Caused by Schistosomiasis. J Korean Neurosurg Soc. 2010. 47:151–154.

98. Korea Centers for Disease Control and Prevention (KCDC). http://www.cdc.go.kr/kcdchome/jsp/observation/stat/submain/subMain.jsp?pageNum=1&sub=3.

99. Yu JR, Sohn WM. A case of human cyclosporiasis causing traveler's diarrhea after visiting Indonesia. J Korean Med Sci. 2003. 18:738–741.

100. Morris DL, Richards KS. Hydatid Disease: Current Medical and Surgical Management. 1992. Oxford: Butterworth-Heineman.

101. Suwan Z. Sonographic findings in hydatid disease of the liver: Comparison with other imaging methods. Ann Trop Med Parasitol. 1995. 89:261–269.

102. Macpherson CNL, Bartholomot B, Frider B. Application of ultrasound in diagnosis, treatment, epidemiology, public health and control of Echinococcus granulosus and E. multilocularis. Parasitology. 2003. 127:Suppl. S21–S35.

103. Maddison SE, Slemenda SB, Schantz PM, Fried JA, Wilson M, Tsang VC. A specific diagnostic antigen of Echinococcus granulosus with an apparent molecular weight of 8 Kda. Am J Trop Med Hyg. 1989. 40:377–383.

104. Moro PL, Gilman RH, Wilson M, Schantz PM, Verastegui M, Garcia HH, Miranda E. Immunoblot (western blot) and double diffusion (DD5) tests for hydatid disease cross-react with sera from patients with cysticercosis. Trans R Soc Trop Med Hyg. 1992. 86:422–423.

105. Gil-Grande LA, Rodriguez-Caabeiro F, Prieto JG, Sánchez-Ruano JJ, Brasa C, Aguilar L, García-Hoz F, Casado N, Bárcena R, Alvarez AI, Dal-Re R. Randomised controlled trial of efficacy of albendazole in intra-abdominal hydatid disease. Lancet. 1993. 342:1269–1272.

106. Franchi C, DiVico B, Teggi A. Long-term evaluation for patients with hydatidosis treated with benzimidazole carbamates. Clin Infect Dis. 1999. 29:304–309.

107. Horton J. Albendazole for the treatment of echinococcosis. Fundam Clin Pharmacol. 2003. 17:205–212.

108. Kern P. Echinococcus granulosus infection: Clinical presentation, medical treatment and outcome. Langenbecks Arch Surg. 2003. 388:413–420.

109. Chai J, Menghebat , Jiao W, Sun D, Liang B, Shi J, Fu C, Li X, Mao Y, Wang X, Dolikun , Guliber , Wang Y, Gao F, Xiao S. Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis. Chin Med J (Engl). 2002. 115:1809–1813.

110. Park KH, Jung SI, Jang HC, Shin JH. First successful puncture, aspiration, injection, and re-aspiration of hydatid cyst in the liver presenting with anaphylactic shock in Korea. Yonsei Med J. 2009. 50:717–720.

111. Chung KY, Lee DY, Hong PW. Surgical treatment of pulmonary hydatid cyst-two case reports. Korean J Thorac Cardiovasc Surg. 1983. 16:518–525.

112. Jeon SH, Seo M, Suh KS, Lee SH. Laparoscopic treatment of isolated renal hydatid cyst. Korean J Urol. 2007. 48:555–557.

113. Choi JY, Seo M, Suh KS, Lee SH. An imported case of hepatic unilocular hydatid disease. Korean J Parasitol. 1995. 33:125–130.

114. Choi KH, Kim MH, Choi JW, Suh JT. A case of echinococcal infection. Korean J Clin Pathol. 1996. 16:704–709.

115. Kim IK, Kim DY, Moon I, Kim TS, Ock MS, Oh KS, Rhew HY. A case of echinococcal hydatid cyst as misdiagnosed to the bladder cancer. Korean J Urol. 2004. 45:1292–1295.

116. Ryou JY, Kim KH, Kim SY. Hydatid cyst of the orbit. J Korean Ophthalmol Soc. 2006. 47:484–488.

117. Kang MJ, Lee SH, Kim SJ, Chei YH, Park JH, Park DH, Park SH, Kin SJ. A case of multiple intraperitoneal cyst from ruptured hepatic hydatid cysts. Korean J Gastroenterol. 2007. 50:203–206.

118. Suh JH, Kim YH. Pulmonary hydatid cyst found in a forein worker from endemic area: case report. Korean J Thorac Cardiovasc Surg. 2008. 41:527–531.

119. Kim IY, Kim SW, Shin HC, Han JK. US and CT findings of splenic hydatid cyst: case report. J Korean Soc Ultrasound Med. 2009. 28:39–42.

120. Kang J, Jung BC, Lee SB, Hong SK, Jeong H, Kim SH, Lee SE. A case of recurred hydatid cyst in pelvic cavity. Korean J Urol. 1999. 40:937–940.

121. Ahn MH. Traveling and imported parasitic deseases. J Korean Med Assoc. 2007. 50:993–1004.

122. Caumes E, Carrière J, Guermonprez G, Bricaire F, Danis M, Gentilini M. Dermatoses associated with travel to tropical countries: A prospective study of the diagnosis and management of 269 patients presenting to a tropical disease unit. Clin Infect Dis. 1995. 20:542–548.

123. Caumes E. Treatment of cutaneous larva migrans. Clin Infect Dis. 2000. 30:811–814.

124. Bouchaud O, Houzé S, Schiemann R, Durand R, Ralaimazava P, Ruggeri C, Coulaud JP. Cutaneous larva migrans in travelers: A prospective study, with assessment of therapy with ivermectin. Clin Infect Dis. 2000. 31:493–498.

125. Lim MH, Lee SC, Won YH, Chun IK. A case of creeping eruption. Korean J Dermatol. 1996. 34:485–488.

126. Lee SJ, Moon TK, Hann SK. Two cases of cutaneous larva migrans. Ann Dermatol. 1998. 10:61–63.

127. Kim JW, Kim DJ, Kim IH, Song HJ, Oh CH. A case of cutaneous larva migrans. Korean J Dermatol. 1999. 37:423–426.

128. Chang SE, Ser CW, Choi JH, Sung KJ, Moon KC, Koh JK. A case of cutaneous larva migrans showing a larva on biopsy. Korean J Dermatol. 1999. 37:547–549.

129. Park JW, Kwon SJ, Ryu JS, Hong EK, Lee JU, Yu HJ, Ahn MH, Min DY. Two imported cases of cutaneous larva migrans. Korean J Parasitol. 2001. 39:77–81.

130. Kim YT, Song MH, Lee SY, Lee JS, Hwang KW. A case of cutaneous larva migranss. Korean J Dermatol. 2002. 40:209–211.

131. You DO, Kang JD, Youn NH, Park SD. A case of creeping eruption. Korean J Dermatol. 2002. 40:461–463.

132. Suh HS, Jee MS, Kim HH, Choi JH, Sung KJ, Moon KC, Koh JK. Two cases of cutaneous larva migrans. Korean J Dermatol. 2003. 41:92–95.

133. Kwon IH, Kim HS, Lee JH, Choi MH, Chai JY, Nakamujra-Uchiyama F, Nawa Y, Cho KH. A serologically diagnosed human case of cutaneous larva migrans caused Ancylostoma caninum. Korean J Parasitol. 2003. 41:233–237.

134. Kim TH, Lee BS, Sohn WM. Three clinical cases of cutaneous larva migrans. Korean J Parasitol. 2006. 44:145–149.

135. Yong TS, Shin HJ, Im KI, Kim WH. An imported human case of hookworm infection with worms in the rectum. Korean J Parasitol. 1992. 30:59–62.

136. Kim HY, Lee SM, Joo JE, Na MJ, Ahn MH, Min DY. Human syngamosis: The first case of Korea. Thorax. 1998. 53:717–718.

137. Brabin BJ. Analysis of malaria in pregnancy in Africa. Bull World Health Organ. 1983. 61:1005–1016.

138. World Health Organization: Control of Tropical Diseases. Severe and Complicated Malaria, 2nd ed. Trans R Soc Trop Med Hyg. 1990. 84:Suppl 2. 1–65.

139. Shulman CE, Dorman EK. Importance and prevention of malaria in pregnancy. Trans R Soc Trop Med Hyg. 2003. 97:30–35.

140. McGready R, Thwai KL, Chot T, Samuel , Looareesuwan S, White NJ, Nosten Fl. The effects of quinine and chloroquine antimalarial treatment in the first trimaster of pregnancy. Trans R Soc Trop Med Hyg. 2002. 96:180–184.

141. Steketee RW, Wirima JJ, Slutsker L, Khoromana CO, Heymann DL, Breman JG. Malaria treatment and prevention in pregnancy: Indications for use and adverse events associated with use of chloroquine or mefloquine. Am J Trop Med Hyg. 1996. 55:1 Suppl. 50–56.

142. Nosten F, Vincenti M, Simpson J, Yei P, Thwai KL, de Vried A, Chongsuphajasisiddhi T, White NJ. The effects of mefloquine treatment in pregnancy. Clin Infect Dis. 1999. 28:808–815.

143. Adam I, Ali DA, Alwaseila A, Kheir MM, Elbashir MI. Mefloquine in the treatment of falciparum malaria during pregnancy in Eastern Sudan. Saudi Med J. 2004. 25:1400–1402.

144. McGready R, Keo NK, Villegas L, White NJ, Looareesuwan S, Nosten F. Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report. Trans R Soc Trop Med Hyg. 2003. 97:592–594.

145. ter Kuile FO, Parise ME, Verhoeff FH, Udhayakumar V, Newman RD, van Eijk AM, Rogerson SJ, Steketee RW. The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub-Saharan Africa. Am J Trop Med Hyg. 2004. 71:2 Suppl. 41–54.

146. Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A. Effect of HIV-1 and increasing immunosuppression on malaria parasitemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet. 2000. 356:1051–1056.

147. Francesconi P, Fabiani M, Dente MG, Lukwiya M, Okwey R, Ouma J, Ochakachon R, Cian F, Declich S. HIV, malaria parasites, and acute febrile episodes in Ugandan adults: a case-control study. AIDS. 2001. 15:2445–2550.

148. French N, Nakiyingi J, Lugada E, Watera C, Whitworth JA, Gilks CF. Increasing rate of malarial fever with deteriorating immune status in HIV-1 infected Ugandan adults. AIDS. 2001. 15:899–906.

149. Ferreira MS, Nishioka Sde A, Silvestre MT, Borges AS, Nunes-Araujo FR, Rocha A. Reactivation of Chagas' disease in patients with AIDS: Report of three new cases and review of the literature. Clin Infect Dis. 1997. 25:1397–1400.

150. Silva N, O'Bryan L, Medeiros E, Holand H, Suleiman J, de Mendonca JS, Patronas N, Reed SG, Klein HG, Masur H, Badaro R. Trypanosoma cruzi meningoencephalitis in HIV-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol. 1999. 20:342–349.

151. Luft BJ, Remington JS. AIDS commentary. Toxoplasmic encephalitis. J Infect Dis. 1988. 157:1–6.

152. Sison JP, Kemper CA, Loveless M, McShane D, Visvesvara GS, Deresinski SC. Disseminated acanthamoeba infection in patients with AIDS: case reports and review. Clin Infect Dis. 1995. 20:1207–1216.

153. Vakil NB, Schwartz SM, Buggy BP, Brummitt CF, Kherellah M, Letzer DM, Gilson IH, Jones PG. Biliary cryptosporidiosis in HIV-infected people after the waterborne outbreak of cryptosporidiosis in Milwaukee. N Engl J Med. 1996. 334:19–23.