J Korean Soc Transplant.  2011 Dec;25(4):245-248. 10.4285/jkstn.2011.25.4.245.

Paranasal Aspergillosis in Patients Prior to Liver Transplantation

• Kim BG
• Roh Y
• Moon H
• Kim TS
• Lee S
• Song S
• Shin M
• Kim JM
• Kwon CH
• Kim SJ
• Joh JW
• Lee SK

• KMID: 1450972
• DOI: http://doi.org/10.4285/jkstn.2011.25.4.245

Abstract

BACKGROUND
Aspergillosis infection is associated with high morbidity and mortality in liver transplant recipients. This study investigated the prognosis of liver transplant recipients with a pre-operative treatment for paranasal aspergillosis.
METHODS
We collected data from 979 cases of patients who underwent liver transplants at the Samsung Medical Center from May 1996 to Feburary 2010.
RESULTS
Eight patients were diagnosed with paranasal aspergillosis after functional endoscopic sinus surgery (FESS), before liver transplantation. In these 8 patients, 7 (87.5%) were male, with a mean age of 55 years. All patients had a hepatitis B virus infection, and 6 patients had hepatocellular carcinoma. The mean days from FESS to liver transplantation was 31 (range, 12~47 days) and anti-fungal agents were not used during these periods. All 8 patients were free from a recurrence of aspergillosis after liver transplantation.
CONCLUSIONS
Surgical treatment for paranasal aspergillosis in patients prior to liver transplantation does not induce aspergillosis infection after transplantation.

Keyword

Fungal infection; Liver transplantation; Aspergillosis; Functional endoscopic sinus surgery

MeSH Terms

Aspergillosis
Carcinoma, Hepatocellular
Hepatitis B virus
Humans
Liver
Liver Transplantation
Male
Prognosis
Recurrence
Transplants

Figure

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  Fig. 1. OMU-CT shows the calcification of left maxillary sinus.

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  Fig. 2. Microscopic finding of paranasal aspergilloma shows fungal hyphae (Periodic Acid-Schiff Stain).

Reference

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