Korean J Otorhinolaryngol-Head Neck Surg.
2011 Feb;54(2):148-153. 10.3342/kjorl-hns.2011.54.2.148.
Voice Characteristics of Adductor Spasmodic Dysphonia before and after Botulinum Toxin-A Injection
- Affiliations
-
- 1Department of Otorhinolaryngology, Institute of Logopedics and Phoniatrics, Yonsei University College of Medicine, Seoul, Korea. hschoi@yuhs.ac
- 2Speech and Language Pathology, Yonsei University Graduate School, Seoul, Korea.
- 3Department of Rehabilitation Medicine, Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Speech and Language Pathology, Myongji University Graduate School, Seoul, Korea.
- KMID: 1446465
- DOI: http://doi.org/10.3342/kjorl-hns.2011.54.2.148
Abstract
- BACKGROUND AND OBJECTIVES
Botulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of "Spasmodic dysphonia". However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A.
SUBJECTS AND METHOD
The study examined 12 female patients with 'adductor spasmodic dysphonia'. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale.
RESULTS
Aerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequency distribution was significantly increased, while the mean amplitude and the mean closed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient self-rating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life.
CONCLUSION
Our results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.
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