Lab Anim Res.  2011 Dec;27(4):301-307. 10.5625/lar.2011.27.4.301.

Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats

• Choi SY
• Park D
• Yang G
• Lee SH
• Bae DK
• Hwang SY
• Lee PK
• Kim YB
• Kim IH
• Kang HG

• KMID: 1444962
• DOI: http://doi.org/10.5625/lar.2011.27.4.301

Abstract

This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats were divided randomly into 3 groups: sham-operated group (sham), ovariectomized group (OVX) and SAC-treatment group (OVX+SAC). The OVX+SAC group was given drinking water containing 0.0012% SAC for 12 weeks. Bone breaking force and mineralization as well as blood parameters related to the bone metabolism were analyzed. In OVX animals, blood concentration of 17beta-estradiol decreased significantly, while osteocalcin and type I collagen C-terminal telopeptides (CTx) increased. Breaking force, bone mineral density (BMD), calcium and phosphorus in femurs, as well as uterine and vaginal weights, decreased significantly following OVX. However, SAC treatment (0.0012% in drinking water) not only remarkably restored the decreased 17beta-estradiol and increased osteocalcin and CTx concentrations, but also recovered decreased femoral breaking force, BMD, calcium and phosphorus, although it did not reversed reproductive organ weights. It is suggested that SAC effectively improve bone density by preventing bone turnover mediated osteocalcin, CTx and minerals, and that it could be a potential candidate for therapy or prevention of postmenopausal osteoporosis.

Keyword

Osteoporosis; bone mineral density; Sigma Anti-bonding Molecule Calcium Carbonate; 17beta-estradiol; osteocalcin; type I collagen C-terminal telopeptides

MeSH Terms

Animals
Bone Density
Calcium
Calcium Carbonate
Collagen Type I
Drinking
Drinking Water
Female
Femur
Humans
Minerals
Organ Size
Osteocalcin
Osteoporosis
Osteoporosis, Postmenopausal
Phosphorus
Rats
Rats, Sprague-Dawley
Weights and Measures
Calcium
Calcium Carbonate
Collagen Type I
Drinking Water
Minerals
Osteocalcin
Phosphorus

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