Tuberc Respir Dis.  2011 Feb;70(2):139-142. 10.4046/trd.2011.70.2.139.

Cutaneous Metastasis from Lung Cancer: A Single-Institution Retrospective Analysis

Affiliations
  • 1Department of Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological & Medical Sciences, Seoul, Korea. jclee@kcch.re.kr

Abstract

BACKGROUND
Lung cancer is responsible for substantial proportions of cutaneous metastasis from internal malignancies. The aim of this study was to evaluate the clinical manifestations and outcomes of cutaneous metastasis in Korean lung cancer patients.
METHODS
On a retrospective basis, we analyzed medical records of all patients diagnosed with lung cancer from 2000 to 2006.
RESULTS
Cutaneous metastases were found in 10 of 4,385 patients. The number of cases was highest for squamous cell carcinoma. However, there was no metastasis from 754 cases of small cell carcinomas. Cutaneous metastasis was detected during staging work-up in 4 patients and it was the presenting sign of recurrence post-operative in 2 patients. Average time from the diagnosis to discovery of cutaneous metastasis was 16.3 months and median survival was 8.5 months (range, 1.8~19.1 months).
CONCLUSION
Physicians should be acquainted with clinical manifestations and outcomes of cutaneous metastasis from lung cancer to detect new, recurrent cancer, or disease progression, and to administer appropriate and prompt management.

Keyword

Lung neoplasms; Neoplasm Metastasis; Skin neoplasms

MeSH Terms

Carcinoma, Small Cell
Carcinoma, Squamous Cell
Disease Progression
Humans
Lung
Lung Neoplasms
Medical Records
Neoplasm Metastasis
Recurrence
Retrospective Studies
Skin Neoplasms

Reference

1. Nashan D, Müller ML, Braun-Falco M, Reichenberger S, Szeimies RM, Bruckner-Tuderman L. Cutaneous metastases of visceral tumours: a review. J Cancer Res Clin Oncol. 2009. 135:1–14.
2. Hu SC, Chen GS, Wu CS, Chai CY, Chen WT, Lan CC. Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center. J Am Acad Dermatol. 2009. 60:379–387.
3. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J. 2003. 96:164–167.
4. Hu SC, Chen GS, Lu YW, Wu CS, Lan CC. Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal. J Eur Acad Dermatol Venereol. 2008. 22:735–740.
5. Mueller TJ, Wu H, Greenberg RE, Hudes G, Topham N, Lessin SR, et al. Cutaneous metastases from genitourinary malignancies. Urology. 2004. 63:1021–1026.
6. Hidaka T, Ishii Y, Kitamura S. Clinical features of skin metastasis from lung cancer. Intern Med. 1996. 35:459–462.
7. Terashima T, Kanazawa M. Lung cancer with skin metastasis. Chest. 1994. 106:1448–1450.
8. Kamble R, Kumar L, Kochupillai V, Sharma A, Sandhoo MS, Mohanti BK. Cutaneous metastases of lung cancer. Postgrad Med J. 1995. 71:741–743.
9. Perng DW, Chen CH, Lee YC, Perng RP. Cutaneous metastasis of lung cancer: an ominous prognostic sign. Zhonghua Yi Xue Za Zhi (Taipei). 1996. 57:343–347.
10. Rubinstein RY, Baredes S, Caputo J, Galati L, Schwartz RA. Cutaneous metastatic lung cancer: literature review and report of a tumor on the nose from a large cell undifferentiated carcinoma. Ear Nose Throat J. 2000. 79:96–97. 100–101.
11. Barbetakis N, Samanidis G, Paliouras D, Samanidou E, Tzimorota Z, Asteriou C, et al. Facial skin metastasis due to small-cell lung cancer: a case report. J Med Case Reports. 2009. 3:32.
12. Coslett LM, Katlic MR. Lung cancer with skin metastasis. Chest. 1990. 97:757–759.
13. Brownstein MH, Helwig EB. Spread of tumors to the skin. Arch Dermatol. 1973. 107:80–86.
14. Chee RJ, Bydder S, Cameron F. Prolonged survival after resection and radiotherapy for solitary brain metastases from non-small-cell lung cancer. Australas Radiol. 2007. 51:186–189.
15. Mercier O, Fadel E, de Perrot M, Mussot S, Stella F, Chapelier A, et al. Surgical treatment of solitary adrenal metastasis from non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005. 130:136–140.
16. Kim MS, Kook EH, Ahn SH, Jeon SY, Yoon JH, Han MS, et al. Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation. J Cancer Res Clin Oncol. 2009. 135:297–301.
Full Text Links
  • TRD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr