J Korean Soc Radiol.  2012 Feb;66(2):155-158. 10.3348/jksr.2012.66.2.155.

Plexiform Schwannoma of the Stomach in Neurofibromatosis Type 2: A Case Report

• Yeom DH
• Cho HS
• Kim HJ
• Cho WH
• Kim JH
• Jeong MJ
• Kim SH
• Kim JY
• Kim SH
• Kang MJ
• Lee J
• Lee HB

• KMID: 1439407
• DOI: http://doi.org/10.3348/jksr.2012.66.2.155

Abstract

Plexiform schwannoma is a relatively rare benign subepithelial tumor arising from the peripheral nerve sheath, and associated with Neurofibromatosis type 2 (NF2). There are a few reports of plexiform schwannomas arising from the gastrointestinal tract, and to our knowledge, there is no report of it arising from the stomach in a patient with NF2. Here we present the first case of a plexiform schwannoma of the stomach in an NF2 patient a submucosal tumor on radiologic finding.

MeSH Terms

Gastrointestinal Tract
Humans
Neurilemmoma
Neurofibromatoses
Neurofibromatosis 2
Peripheral Nerves
Stomach

Reference

1. Retrosi G, Nanni L, Ricci R, Manzoni C, Pintus C. Plexiform schwannoma of the esophagus in a child with neurofibromatosis type 2. J Pediatr Surg. 2009. 44:1458–1461.

2. Evans DG. Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis. 2009. 4:16.

3. Miyakawa T, Kamada N, Kobayashi T, Hirano K, Fujii K, Sasahara Y, et al. Neurofibromatosis type 2 in an infant with multiple plexiform schwannomas as first symptom. J Dermatol. 2007. 34:60–64.

4. Iida A, Imamura Y, Katayama K, Hirose K, Yamaguchi A. Plexiform schwannoma of the small intestine: report of a case. Surg Today. 2003. 33:940–943.

5. Cokelaere K, Sciot R, Geboes K. Esophageal Plexiform Schwannoma. Int J Surg Pathol. 2000. 8:353–357.

6. Agaram NP, Prakash S, Antonescu CR. Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. Am J Surg Pathol. 2005. 29:1042–1048.

7. Hirose T, Scheithauer BW, Sano T. Giant plexiform schwannoma: a report of two cases with soft tissue and visceral involvement. Mod Pathol. 1997. 10:1075–1081.

8. Coron R, Boucard H, Richards R. Case report: sigmoid schwannoma as the lead point for intussusception in an adult patient with neurofibromatosis. Department of Medicine Faculty of Papers 8-9-2006.

9. Jacobson BC, Hirsch MS, Lee JH, Van Dam J, Shoji B, Farraye FA. Multiple asymptomatic plexiform schwannomas of the sigmoid colon: a case report and review. Gastrointest Endosc. 2001. 53:801–804.