Korean J Clin Microbiol.  2012 Jun;15(2):54-59. 10.5145/KJCM.2012.15.2.54.

Epidemiologic Features of Parainfluenza Virus Type 1, 2 and 3 Infection in Seoul and a Neighboring Area, 2008-2011

• Lee H
• Lee CK
• Nam MH
• Roh KH
• Yoon SY
• Lim CS
• Cho Y
• Kim YK
• Lee KN
• Yoo Y

• KMID: 1434173
• DOI: http://doi.org/10.5145/KJCM.2012.15.2.54

Abstract

BACKGROUND
Parainfluenza virus (PIV) is a significant cause of acute respiratory infections. Epidemiological information on PIV infection could be very helpful for patient management. The aim of this study was to investigate the epidemiology of PIV infection in Seoul and a neighboring area with regard to PIV type.
METHODS
The diagnosis of PIV infection was made by virus isolation. The R-mix Too cell system (Diagnostic Hybrids, Inc., Athens, OH, USA) and D3 Ultra DFA Respiratory Virus Screening & ID kits (Diagnostic Hybrids, Inc.) were used for virus culture and identification. The medical records of patients with positive virus cultures were reviewed retrospectively.
RESULTS
Seven hundred and ten PIV viruses (5.6%) were isolated from 12,723 specimens. The number of subjects with PIV type III, I and II was 357, 304 and 49, respectively. PIV infection showed a peak incidence in the first year of life regardless of subtypes. The most common diagnosis among all PIV subtypes was pneumonia. Lower respiratory tract infections constituted the majority (76.3%) of PIV infections. The most common diagnosis of PIV type I and II was croup and that of PIV type III was pneumonia. A difference in seasonal variation between subtypes was observed. PIV I (62.2%) was mainly isolated from July to September while PIV type III (86.8%) was isolated from April to July.
CONCLUSION
Lower respiratory infection was most commonly found in hospitalized patients with PIV infection. Clinical features of PIV infection were similar those seen in Western PIV reports, with the exception of the seasonal outbreak pattern.

Keyword

Epidermiology; Parainfluenza virus; Respiratory tract infection

MeSH Terms

Chimera
Croup
Humans
Incidence
Mass Screening
Medical Records
Parainfluenza Virus 1, Human
Paramyxoviridae Infections
Pneumonia
Respiratory Tract Infections
Seasons
Viruses

Figure

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  Fig. 1 Counts of parainfluenza virus -1, -2, and -3 isolates by month of year for 2008-2011.

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  Fig. 2 Virus type (number of isolates according to age, years). Abbreviation: See Table 1.

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