Gut Liver.
2013 May;7(3):303-310. 10.5009/gnl.2013.7.3.303.
Prevalence and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia: A Nationwide Multicenter Prospective Study in Korea
- Affiliations
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- 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. nayoungkim49@empas.com
- 3Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
- 4Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 5Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
- 6Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
- 7Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
- 8School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.
- KMID: 1431346
- DOI: http://doi.org/10.5009/gnl.2013.7.3.303
Abstract
- BACKGROUND/AIMS
Atrophic gastritis (AG) and intestinal metaplasia (IM) are premalignant gastric lesions. The aims of this study were to evaluate the prevalence of endoscopic AG and IM and to document the risk factors for these lesions.
METHODS
In total, 4,023 subjects were enrolled at eight hospitals in Korea. AG and IM were diagnosed by endoscopy. Helicobacter pylori immunoglobulin G antibodies were measured.
RESULTS
The prevalences of endoscopic AG and IM were 40.7% and 12.5%. In a multivariate analysis, the risk factors for AG were age groups of 40 to 59 years and >60 years, male sex, positive H. pylori serology, IM, and education below the college level (odds ratio [OR], 2.55, 5.00, 1.38, 1.41, 4.29, and 1.35, respectively). The risk factors for IM were age groups of 40 to 59 years and >60 years, male sex, positive H. pylori serology, AG, having relatives with gastric cancer, education below the college level and consumption of dairy products (OR, 3.16, 3.25, 1.88, 2.17, 3.68, 1.48, 1.47, and 1.40, respectively).
CONCLUSIONS
A nationwide survey regarding the prevalence of endoscopic AG and IM and their risk factors in Korea supports the hypothesis that endoscopic diagnosis of these premalignant lesions could be helpful to describe a group at high risk for gastric cancer.
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