J Korean Assoc Oral Maxillofac Surg.  2013 Jun;39(3):139-143. 10.5125/jkaoms.2013.39.3.139.

Occurrence of multiple myeloma in the head and neck: a report of two cases

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hongjr@skku.edu

Abstract

Multiple myeloma (MM) is a disease reported to account for 1% of all cancers and 10% of hematological malignant diseases. Unlike other malignant diseases that are transferred to the osseous tissues, MM does not show new bone formation, is associated with characteristic osteolytic lesions, and shows monoclonal protein (M-protein) on the immunohematological test, which is an important index in its diagnosis. Solitary lesions of MM are rare in the head and neck area, and, in most cases, MM of the head and neck area is related to systemic sympomts.

Keyword

Multiple myeloma; Plasmacytoma; Plasma cell

MeSH Terms

Head
Multiple Myeloma
Neck
Osteogenesis
Plasma Cells
Plasmacytoma

Figure

  • Fig. 1 Figures of Case 1. A. Intraoral clinical photo. Reddish swelling was seen with the #22 and 23 teeth. B. Computed tomography image. The left maxilla cortical bone disappeared.

  • Fig. 2 Figures of Case 2. A. Pre-radiotherapy intraoral clinical photo. B. Pre-radiotherapy positron emission tomogrphy image. Note the hot spots on the left side.

  • Fig. 3 Figures of Case 2. A. Post-radiotherapy intraoral clinical photo. Healing mucosa was noted. B. Post-radiotherapy positron emission tomogrphy scan. Hot spots disappeared.

  • Fig. 4 Figure of Case 2. Recurring multiple myeloma.


Reference

1. Landgren O, Weiss BM. Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis. Leukemia. 2009; 23:1691–1697. PMID: 19587704.
Article
2. Stoopler ET, Vogl DT, Stadtmauer EA. Medical management update: multiple myeloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103:599–609. PMID: 17291793.
Article
3. Canger EM, Celenk P, Alkan A, Günhan O. Mandibular involvement of solitary plasmocytoma: a case report. Med Oral Patol Oral Cir Bucal. 2007; 12:E7–E9. PMID: 17195833.
4. Tournier-Rangeard L, Lapeyre M, Graff-Caillaud P, Nege A, Dolivet G, Toussaint B, et al. Radiotherapy for solitary extramedullary plasmacytoma in the head-and-neck region: A dose greater than 45 Gy to the target volume improves the local control. Int J Radiat Oncol Biol Phys. 2006; 64:1013–1017. PMID: 16343803.
Article
5. Rajkumar SV. Treatment of multiple myeloma. Nat Rev Clin Oncol. 2011; 8:479–491. PMID: 21522124.
Article
6. Bruce KW, Royer RQ. Multiple myeloma occurring in the jaws; a study of 17 cases. Oral Surg Oral Med Oral Pathol. 1953; 6:729–744. PMID: 13063932.
7. Baykul T, Aydin U, O Carroll MK. Unusual combination of presenting features in multiple myeloma. Dentomaxillofac Radiol. 2004; 33:413–419. PMID: 15665237.
Article
8. International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003; 121:749–757. PMID: 12780789.
9. Cesana C, Klersy C, Barbarano L, Nosari AM, Crugnola M, Pungolino E, et al. Prognostic factors for malignant transformation in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. J Clin Oncol. 2002; 20:1625–1634. PMID: 11896113.
Article
10. Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol. 2005; 23:6333–6338. PMID: 16155016.
Article
11. Creach KM, Foote RL, Neben-Wittich MA, Kyle RA. Radiotherapy for extramedullary plasmacytoma of the head and neck. Int J Radiat Oncol Biol Phys. 2009; 73:789–794. PMID: 18707826.
Article
Full Text Links
  • JKAOMS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr