Obstet Gynecol Sci.  2013 Mar;56(2):121-125. 10.5468/OGS.2013.56.2.121.

Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy

• Yun NR
• Park JW
• Hyun MK
• Park JH
• Choi SJ
• Song E

• KMID: 1425659
• DOI: http://doi.org/10.5468/OGS.2013.56.2.121

Abstract

Mature cystic teratomas of the ovary (MCT) are usually observed in women of reproductive age with the most dreadful complication being malignant transformation which occurs in approximately 1% to 3% of MCTs. In this case report, we present a patient with squamous cell carcinoma which developed from a MCT during pregnancy. The patient was treated conservatively without adjuvant chemotherapy and was followed without evidence of disease for more than 60 months using conventional tools as well as positron emission tomography-computed tomography following the initial surgery. We report this case along with the review of literature.

Keyword

Dermoid cyst; Malignant transformation; Observation; Positron emission tomography-computed tomography

MeSH Terms

Carcinoma, Squamous Cell
Chemotherapy, Adjuvant
Dermoid Cyst
Electrons
Female
Humans
Ovary
Pregnancy
Teratoma

Figure

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  Fig. 1 (A) Sonography shows intrauterine pregnancy at 8+5 weeks of gestation. (B) Sonography shows about 18 cm solid and cystic left ovarian mass. (C) The specimen obtained shows huge cystic and solid left ovary with smooth surface and two small right ovarian cysts.

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  Fig. 2 (A) The ovarian cyst filled with sebaceous material shows a protuberance covered with hair tuffs (arrowhead). Cut surface of the protuberance discloses a cauliflower-like solid mass (arrow) protruding into the cyst. (B) A typical squamous cell carcinoma arises in the epidermal component (H&E, ×12.5). (C) Transition from benign epidermal tissue to squamous cell carcinoma with invasive growth is evident (H&E, ×40). (D) Mature glial tissue is partly invaded by squamous cell carcinoma (arrow) (H&E, ×200).

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