Hip Pelvis.  2012 Dec;24(4):265-272. 10.5371/hp.2012.24.4.265.

Animal Experiment of Legg-Calve-Perthes Disease in Piglets, Puppies and Growing Rabbits

• Rowe SM

• KMID: 1425041
• DOI: http://doi.org/10.5371/hp.2012.24.4.265

Abstract

No abstract available.

MeSH Terms

Animal Experimentation
Animals
Legg-Calve-Perthes Disease
Rabbits

Figure

• 

  Fig. 1 (A-C) Photographs of animal models of LCPD in piglets, puppies, and growing rabbits.

• 

  Fig. 2 (A-D) Composite radiographic findings from extracted femurs from a piglets sacrificed at postoperative week 4 (A), 8 (B), 12 (C), and 16 (D) showing gradual increase of coxa plana, coxa magna, and greater trochanter overgrowths.

• 

  Fig. 3 (A) Radiography of the extractred femurs from a puppy of Group C at postoperative two months showing a decrease in epiphyseal height and cystic changes of the ossific nucleus at left operated femur. (B) Macroscopic photography showing shortening of 2.5 mm with a mild degree of medial bowing of the femoral neck at left operated femur. (C-D) Macroscopic appearances of both extracted femurs five months after operation showing remarkable increase in anteversion and coxa magna of the operated left femur.

• 

  Fig. 4 (A) Radiograph before surgery showing normal hip of 5 week-year-old rabbit. (B) Radiograph at postoperative 4 weeks showing coxa vara and greater trochanter (GT) overgrowth. (C) Radiograph at 12 weeks showing further increase of deformities. (D) Macroscopic finding of extracted femur showing coxa magna, coxa vara, and GT overgrowth.

Reference

1. Catterall A. The natural history of Perthes' disease. J Bone Joint Surg Br. 1971. 53:37–53.

2. Babyn PS, Kim HK, Gahuunia HK, et al. MRI of the cartilaginous epiphysis of the femoral head in the piglet hip after ischemic damage. J Magn Reson Imaging. 1998. 8:717–723.

3. Kim HK, Su PH. Development of flattening and apparent fragmentation following ischemic necrosis of the capital femoral epiphysis in a piglet model. J Bone Joint Surg Am. 2002. 84-A:1329–1334.

4. Rowe SM, LEE JJ, Chung JY, Moon ES, Song EK, Seo HY. Deformity of the femoral head following vascular infarct in piglets. Acta Orthop. 2006. 77:33–38.

5. Rowe SM, Moon ES, Jung ST, Kim JW, Kim JS, Kim MS. Experimental study of avascular necrosis of the femoral head in the puppy. J Korean Orthop Assoc. 2003. 38:447–453.

6. Sanchis M, Zahir A, Freeman MA. The experimental simulation of Perthes disease by consecutive interruptions of the blood supply to the capital femoral epiphysis in the puppy. J Bone Joint Surg Am. 1973. 55:335–342.

7. Kamegaya M, Shinada Y, Akita T, Ogata S, Someya M, Tsuchiya K. Experimental avascular necrosis of the femoral capital epiphysis and induced subluxation of the hip in young rabbits. J Pediatr Orthop. 1990. 10:1–5.

8. Lemoine A. Vascular changes after interference with the blood flow of the femoral head of the rabbit. J Bone Joint Surg Br. 1957. 39-B:763–777.

9. Rösingh GE, James J. Early phase of avascular necrosis of the femoral head in rabbits. J Bone Joint Surg Br. 1969. 51:165–174.

10. Rowe SM, Chung JY, Moon ES, Jung ST, Lee HJ, Lee JJ. The effects of subluxation of the femoral head with avascular necrosis in growing rabbits. J Pediatr Orthop. 2004. 24:645–650.

11. Rowe SM, Park SK. Necrosis of femoral head in growing rabbit. J Korean Orthop Assoc. 1986. 1:29–34.

12. Yoshiwara S. An experimental study of ischemic damage and repair on the femoral head epiphysis in growing rabbits. Nihon Seikeigeka Gakkai Zasshi. 1994. 68:978–989.

13. Michelsson JE, Langensklöld A. Dislocation or subluxation of the hip. Regular sequels of immobilization of the knee in extension of young rabbits. J Bone Joint Surg Am. 1972. 54:1177–1186.