J Korean Med Sci.  1993 Jun;8(3):202-206. 10.3346/jkms.1993.8.3.202.

Corporeal blood gas changes according to duration of drug-induced prolonged erection

• Kim SC
• Seo KK
• Oh CH

• KMID: 1421976
• DOI: http://doi.org/10.3346/jkms.1993.8.3.202

Abstract

The corporeal blood gas changes in accordance with the duration of the prolonged erection which developed after intracorporeal pharmacotherapy with papaverine and phentolamine were investigated in 62 impotence patients. The picture of the corporeal blood taken from 15 psychogenic impotence patients (a control group) at 10 minutes after intracavernous injection when they showed full erections was arterial but there was pCO2 rise and pH drop compared to femoral artery blood taken simultaneously. As the erection lasted longer, significant gas changes of the cavernous blood began to appear (p<0.0001): increase in pCO2 and decrease in pO2 from 4 hours, decrease in pH from 5 hours, decrease in O2 saturation from 6 hours. Erections lasting for more than 16 hours showed significantly worse hypoxia (p<0.05). Therefore, to prevent hypoxia and metabolic acidosis, drug-induced prolonged erection would be better decompressed before it lasts for more than 4 hours.

Keyword

Corporeal blood gas; Drug-inducedprolonged erection

MeSH Terms

Adult
Carbon Dioxide/*blood
Erectile Dysfunction/*blood/drug therapy
Femoral Artery
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Oxygen/*blood
Papaverine/administration & dosage/therapeutic use
Penile Erection/*drug effects
Phentolamine/administration & dosage/therapeutic use
Time Factors
Carbon Dioxide
Phentolamine
Papaverine
Oxygen