J Korean Med Sci.  1991 Jun;6(2):165-171. 10.3346/jkms.1991.6.2.165.

Solitary myeloma with massive extracellular crystalline structures: a case report

• Kim YG
• Yang KH
• Gang SJ
• Kim BK
• Kim SM

• KMID: 1421850
• DOI: http://doi.org/10.3346/jkms.1991.6.2.165

Abstract

We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not show any myeloma cells. Histologic examination of the tumor revealed aggregation of plasma cells with massive extracellular infiltration of the rhomboid-shaped crystalline structures. In immunoperoxidase staining, both these crystalline structures and the cytoplasms of the myeloma cells demonstrated a positive reaction for lambda light chain. By electron microscope, the large extracellular crystalline structures were observed, and we found unique rhomboid or rectangular-shaped crystalline structures in the cytoplasms of the myeloma cells.

Keyword

Solitary myeloma; Extracellular crystalline structures; Immunoperoxidase staining; Electron microscopy

MeSH Terms

Bone Neoplasms/immunology/*ultrastructure
Crystallization
Extracellular Space/immunology
Female
Humans
Immunoglobulin lambda-Chains/ultrastructure
Microscopy, Electron
Middle Aged
Plasmacytoma/immunology/*ultrastructure
Immunoglobulin lambda-Chains