J Korean Med Sci.  1991 Mar;6(1):55-61. 10.3346/jkms.1991.6.1.55.

Necrotizing lymphadenitis--a clinico-pathologic study of 36 cases with immunohistochemical analysis

• Cho KJ
• Kim CW
• Park SH
• Lee SK

• KMID: 1421515
• DOI: http://doi.org/10.3346/jkms.1991.6.1.55

Abstract

Thirty-six cases of necrotizing lymphadenitis--including 33 cases of unknown etiology, 1 typhoid lymphadenopathy, and 2 cases of suspicious lupus lymphadenopathy--were clinico-pathologically reviewed and analyzed with immunostaining for s-100 and lysozyme. All cases histologically showed architectural effacement by paracortical lesions composed of nuclear karyorrhexis and mononuclear cell proliferation. Immunohistochemical study revealed proliferation of lysozyme-positive macrophages in the necrotizing areas and an increase in the number of s-100-positive cells in the uninvolved paracortical areas. This observation suggests that necrotizing lymphadenitis may be a common morphologic expression of a T cell-mediated hyperimmune condition induced by diverse etiologies.

Keyword

Necrotizing lymphadenitis; Subacute necrotizing lymphadenitis; Immunohistochemistry; S-100 protein; Lysozyme; T cell

MeSH Terms

Adolescent
Adult
Female
Humans
Immunohistochemistry
Lymphadenitis/etiology/metabolism/*pathology
Male
Muramidase/metabolism
Necrosis
S100 Proteins/metabolism
S100 Proteins
Muramidase