J Korean Med Sci.  1990 Sep;5(3):149-154. 10.3346/jkms.1990.5.3.149.

Etiology and outcome of acute viral hepatitis in Korean adults

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Korea.

Abstract

One hundred and sixteen Korean adults with biopsy-proven acute viral hepatitis were studied to determine the etiology and the outcome of the disease using paired sera obtained during acute and convalescent phases. The prevalence of acute viral hepatitis A, B, D and non-A non-B were 3.4%, 60.3%, 0.9% and 35.3%, respectively: hepatitis B virus infection was the most common cause and the hepatitis D virus superinfection was almost negligible. Only eleven (26.8%) of 41 patients with AVH NANB were negative for all serological markers of HBV. The rest (73.2%) were positive for at least one HBV marker: HBsAg was positive in 31.7%. Therefore, the presence of HBV serologic markers in the sera does not exclude the diagnosis of AVH NANB in Korea. In patients with acute viral hepatitis B, 27% remained positive for HBsAg. Chronic hepatitis developed in 12.8% and 17% patients with acute hepatitis B and non-A non-B, respectively. Progression to chronic hepatitis in patients with acute viral hepatitis B and non-A non-B occurred more commonly, although statistically not significant, in male sex and in patients who did not have clinical jaundice during the acute phase and who showed bridging necrosis in their liver biopsies. Age did not influence the progression to chronic hepatitis.

Keyword

Korea; Acute viral hepatitis; Hepatitis B virus; non-A Non-B hepatitis; Hepatitis D virus; Progression to chronic hepatitis

MeSH Terms

Acute Disease
Adolescent
Adult
Aged
Female
Hepatitis, Viral, Human/complications/*microbiology
Humans
Korea
Male
Middle Aged
Prognosis
Risk Factors

Cited by  1 articles

Changes in Liver Stiffness after Acute or Chronic Liver Injury due to Viral Hepatitis - Does Fibrosis Exist after Recovery from Acute Viral Hepatitis?
Jeong Han Kim, Hyung Joon Yim, Seung Young Kim, Jae Hong Ahn, Young Kul Jung, Moon Kyung Joo, Su Hyun Kim, Ji Hoon Kim, Yeon Seok Seo, Jong Eun Yeon, Hong Sik Lee, Soon Ho Um, Sang Woo Lee, Kwan Soo Byun, Jae Hyun Choi, Ho Sang Ryu
Korean J Gastroenterol. 2009;54(3):155-161.    doi: 10.4166/kjg.2009.54.3.155.

Full Text Links
  • JKMS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr