J Korean Med Sci.  1988 Jun;3(2):45-50. 10.3346/jkms.1988.3.2.45.

In vitro activities of eight antibiotics against methicillin-resistant S. aureus and S. epidermidis strains isolated in Korea

• Chang WH
• Choi MS
• Chung HY
• Seo WJ
• Choi TY
• Chong YS
• Kim JS
• Chung SS
• Hong SH

• KMID: 1421285
• DOI: http://doi.org/10.3346/jkms.1988.3.2.45

Abstract

Staphylococcus aureus and Staphylococcus epidermidis strains isolated at eight large medical centers in Korea were examined for methicillin resistance and resistance to eight other antibiotics; cefazolin, cefamandole, cefuroxime, cefoxitin, cefotaxime, moxalactam, penicillin G and vancomycin. Methicillin resistance was found in 296 of 1225 strains (24.2%) of S. aureus and 126 of 348 strains (36.2%) of S. epidermidis. Methicillinresistant strains were isolated from all sources with the frequency of isolation ranging from 11% to 60%. From pleural effusion, throat swab and blood, methicillin-resistant strains of S. aureus were more frequently isolated with statistical significance (Chi-squared test, 95% confidence). Almost all of Methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) strains were multiply resistant to one or more tested eight antibiotics. However only 7(2.4%) of 296 MRSA strains and 2(1.6%) of 126 MRSE strains were resistant to vancomycin. Vancomycin was the most effective antibiotic against staphylococcal isolates as well as MRSA and MRSE.

Keyword

In vitro activities of antibiotics; Methicillin-resistant S.aureus; methicillin-resistant S.epidermidis

MeSH Terms

Anti-Bacterial Agents/*pharmacology
Cross Infection/microbiology
Drug Resistance, Microbial
Humans
Korea
Staphylococcal Infections/microbiology
Staphylococcus aureus/*drug effects/isolation & purification
Staphylococcus epidermidis/*drug effects/isolation & purification
Anti-Bacterial Agents