J Korean Med Sci.  1987 Dec;2(4):213-224. 10.3346/jkms.1987.2.4.213.

A study on the effect of garlic to the heavy metal poisoning of rat

• Cha CW

• KMID: 1421270
• DOI: http://doi.org/10.3346/jkms.1987.2.4.213

Abstract

When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages and the inhibition of serum alkaline phosphatase activities by heavy metals were reduced. Such effect of garlic was not shown in the 1.7% garlic treated group and most remarkable in the 6.7% garlic treated group. The protective effect of garlic was superior to those of 2,3 dimercapto-1-propanol (BAL) and D-penicillamine (PEN), and nearly similar to those of 2,3-dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), the current remedies, while garlic was not effective as a curative agent for heavy metal poisoning. The excretion of cadmium was enhanced, more through feces than urine by garlic but the effect to the urinary excretion of cadmium was not significant comparing with DMSA or APEN when cadmium was ip injected in the first 3 days during the 12 days of oral administration of DMSA, APEN or garlic.

Keyword

Garlic; Cadmium; Mercury; Heavy metal poisoning; Prevention of Heavy Metal Poisoning; Treatment of Heavy Metal Poisoning

MeSH Terms

Animals
Cadmium/metabolism
Cadmium Poisoning/metabolism/*prevention & control
*Garlic
Male
Mercury/metabolism
Mercury Poisoning/metabolism/*prevention & control
*Plants, Medicinal
Rats
Rats, Inbred Strains
Tissue Distribution
Mercury
Cadmium