Exp Mol Med.  2012 Jun;44(6):394-402.

Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women

Affiliations
  • 1Division of Endocrinology and Metabolism, Sanbon Medical Center, University of Wonkwang College of Medicine, Iksan 570-711, Korea.
  • 2Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea. jmkoh@amc.seoul.kr
  • 3Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea. syukim@knu.ac.kr
  • 4The Center for Genome Science, National Institute of Health, Seoul 122-701, Korea.
  • 5Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.
  • 6Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu 700-412, Korea.

Abstract

Adiponectin may affect bone through interactions with two known receptors, adiponectin receptors (ADIPOR) 1 and 2. We examined the association between polymorphisms of ADIPOR1 and ADIPOR2 and bone mineral density (BMD) in postmenopausal Korean women. Six polymorphisms in ADIPOR1 and four polymorphisms in ADIPOR2 were selected and genotyped in all study participants (n = 1,329). BMD at the lumbar spine and femur neck were measured using dual-energy X-ray absorptiometry. Lateral thoracolumbar (T4-L4) radiographs were obtained for vertebral fracture assessment and the occurrence of non-vertebral fractures examined using self-reported data. P values were adjusted for multiple testing using Bonferroni correction (Pcorr). ADIPOR1 rs16850799 and rs34010966 polymorphisms were significantly associated with femur neck BMD (Pcorr = 0.036 in the dominant model; Pcorr = 0.024 and Pcorr = 0.006 in the additive and dominant models, respectively). Subjects with the rare allele of each polymorphism had lower BMD, and association of rs34010966 with BMD showed a gene dosage effect. However, ADIPOR2 single nucleotide polymorphisms and haplotypes were not associated with BMD at any site. Our results suggest that ADIPOR1 polymorphisms present a useful genetic marker for BMD in postmenopausal Korean women.

Keyword

ADIPOR1 protein, human; ADIPOR2 protein, human; bone density; genetic association studies; Korea; osteoporosis, postmenopausal; polymorphism, single nucleotide
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