J Korean Rheum Assoc.  2008 Mar;15(1):70-75. 10.4078/jkra.2008.15.1.70.

A Case of Bronchioloalveolar Carcinoma Presenting Adult-onset Still's Disease-like Manifestations due to Paraneoplastic Syndrome

• Kim HJ
• Kwok SK
• Shin JH
• Cho CS

• KMID: 1324512
• DOI: http://doi.org/10.4078/jkra.2008.15.1.70

Abstract

Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder with the characteristics of high spiking fever, evanescent salmon-colored skin rash, arthralgia or arthritis, lymphadenopathy, hepato-splenomegaly, sore throat, leukocytosis, negative autoantibody and hyperferritinemia. There are reports that rheumatic diseases such as dermatomyositis, polymyositis, hypertrophic osteoarthropathy, and polymyalgia rheumatica are associated with neoplasms. And small cell lung cancer, thymoma, lymphoma, leukemia, and breast cancer are known to be more associated with paraneoplastic syndromes mimicking rheumatic diseases. We experienced a case with bronchioloalveolar carcinoma who developed clinical manifestations of AOSD. Although there are several reports that AOSD is associated with paraneoplastic syndrome, to our knowledge, this is the first case of bronchioloalveolar carcinoma mimicking AOSD reported in the world.

Keyword

Adult-onset Still's disease; Bronchioloalveolar carcinoma; Paraneoplastic syndrome

MeSH Terms

Adult
Male
Female
Humans
Breast Neoplasms
Lung Neoplasms

Figure

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  Fig. 1. Chest PA and Chest CT on admission (A) and 2 months later (B) show 2.8 cm sized, spiculated GGO nodule with air-bronchogram in lateral basal segment of RLL. GGO: ground glass opacity, RLL: right lower lobe of lung.

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  Fig. 2. Bronchioloalveolar carcinoma characterized by tumor cell growing along preexisting alveolar structure (H&E, A: ×100, B: ×400).

Reference

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