J Korean Rheum Assoc.  2008 Mar;15(1):70-75. 10.4078/jkra.2008.15.1.70.

A Case of Bronchioloalveolar Carcinoma Presenting Adult-onset Still's Disease-like Manifestations due to Paraneoplastic Syndrome

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. chocs@catholic.ac.kr
  • 2Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.

Abstract

Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder with the characteristics of high spiking fever, evanescent salmon-colored skin rash, arthralgia or arthritis, lymphadenopathy, hepato-splenomegaly, sore throat, leukocytosis, negative autoantibody and hyperferritinemia. There are reports that rheumatic diseases such as dermatomyositis, polymyositis, hypertrophic osteoarthropathy, and polymyalgia rheumatica are associated with neoplasms. And small cell lung cancer, thymoma, lymphoma, leukemia, and breast cancer are known to be more associated with paraneoplastic syndromes mimicking rheumatic diseases. We experienced a case with bronchioloalveolar carcinoma who developed clinical manifestations of AOSD. Although there are several reports that AOSD is associated with paraneoplastic syndrome, to our knowledge, this is the first case of bronchioloalveolar carcinoma mimicking AOSD reported in the world.

Keyword

Adult-onset Still's disease; Bronchioloalveolar carcinoma; Paraneoplastic syndrome

MeSH Terms

Adult
Male
Female
Humans
Breast Neoplasms
Lung Neoplasms

Figure

  • Fig. 1. Chest PA and Chest CT on admission (A) and 2 months later (B) show 2.8 cm sized, spiculated GGO nodule with air-bronchogram in lateral basal segment of RLL. GGO: ground glass opacity, RLL: right lower lobe of lung.

  • Fig. 2. Bronchioloalveolar carcinoma characterized by tumor cell growing along preexisting alveolar structure (H&E, A: ×100, B: ×400).


Reference

References

1. Bywaters EG. Still's disease in the adult. Ann Rheum Dis. 1971; 30:121–33.
Article
2. Yukiko K, Tetsuo K, Shihoko W, Sae O, Yoshinori N, Hiroyuki H, et al. A case of paraneoplstic syndrome mimicking adult-onset Still's disease. Mod Rheumatol. 2004; 14:410–3.
3. Roques AM, Vidal E, Boudinet F, Loustaud V, Arnaud M, Liozon F. Breast cancer with systemic manifestations mimicking Still's disease. J Rheumatol. 1993; 20:1786–7.
4. Kawasaki T, Hirohata S, Hashimoto T, Miyashita H, Tanaka F. T cell lymphoma masquerading as adult onset Still's disease. Clin Exp Rheumatol. 1995; 13:410–1.
5. David M, Lucian R, Pasi A. Bronchioloalveolar carcinoma: a review of the epidemiology, pathology, and treatment. Semin Respir Crit Care Med. 2005; 26:342–52.
6. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol. 1992; 19:424–30.
7. Kasper D, Braunwald E, Fauci A, Hauser S, Longo D, Jameson J. Harrison's principles of internal medicine. 16th ed.p. 566, New York, McGraw-Hill;2005.
8. Michael A, Stephen B, Gene L, Robin M. Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes. Chest. 2003; 123:97–104.
Article
9. Routier G, Flamencourt P, Watine O, Dansin E. Pseudo-maladie de Still et neoplasie profonde. Rev Med Interne. 1997; 18:47–9.
10. Joung CI, Lee HS, Lee SW, Kim CG, Song YH, Jun JB, et al. Association between HLA-DR B1 and clinical features of adult onset Still's disease in Korea. Clin Exp Rheumatol. 2003; 21:489–92.
11. Wouters JM, van der Veen J, van de Putte LB, de Rooij DJ. Adult onset Still's disease and viral infections. Ann Rheum Dis. 1988; 47:764–7.
Article
12. Hoshino T, Ohta A, Yang D, Kawamoto M, Kikuchi M, Inoue Y, et al. Elevated serum interleukin 6, interferon-gamma, and tumor necrosis factor-alpha levels in patients with adult Still's diseae. J Rheumatol. 1998; 25:396–8.
13. Kawaquchi Y, Terajima H, Hariqai M, Hara M, Kamatani N. Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease. Arthritis Rheum. 2001; 44:1716–7.
14. Takashi F, Yoshinobu I, Sousuke Y, Yoshiki S, Tetsuro B, Yoshika N, et al. Cytokine production of lung cancer cell lines: correlation between their production and the inflammatory/immunological responses both in vivo and in vitro. Cancer Sci. 2007; 98:1048–54.
15. Naumnik W, Chyczewska E, Kovalchuk O, Talalai J, Izycki T, Panek B. Serum level of interleukin-18 (IL-18) and soluble interleukin-2 receptor (sIL-2R) in lung cancer. Rocz Akad Med Bialymst. 2004; 49:246–51.
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