Korean J Urol.  2008 Oct;49(10):893-898. 10.4111/kju.2008.49.10.893.

The Change of Prostate-specific Antigen and Prostate-specific Antigen Density in Patients with Benign Prostatic Hyperplasia after Dutasteride Treatment

• Kim BS
• Yoon YE
• Lee SB
• Park SY
• Son YW
• Kim YT
• Choi HY
• Moon HS

• KMID: 1204318
• DOI: http://doi.org/10.4111/kju.2008.49.10.893

Abstract

PURPOSE: Dihydrotestosterone(DHT) is key to the initiation and maintenance of abnormal prostatic growth in benign prostatic hyperplasia (BPH). Five alpha-reductase inhibitor reduces prostatic growth and serum prostate-specific antigen(PSA) by blocking the conversion of testosterone to DHT. Dutasteride is a dual(type 1 and 2) 5alpha-reductase inhibitor. We evaluated the effects of dutasteride on prostate volume, PSA, and PSA density in men with BPH.
MATERIALS AND METHODS
A total of 83 men with a clinical diagnosis of BPH were treated with dutasteride and an alpha-blocker. We investigated the change in prostate volume, PSA, and PSA density 6 and 12 months after initiation of dutasteride therapy.
RESULTS
After 6 months of dutasteride therapy, the total prostate volume was reduced from baseline by a mean of 15.46%, the PSA was reduced by a mean of 48.24%, and the PSA density was reduced by a mean of 37.97%(p<0.001). After 12 months of dutasteride therapy, the total prostate volume was reduced from baseline by a mean of 23.3%, the PSA was reduced by a mean of 52.57%, and the PSA density was reduced by a mean of 36.2%(p<0.001). There were no differences in the regression rate of PSA and PSA density, in contrast to prostate volume, between 6 and 12 months of dutasteride therapy by repeated measures ANOVA.
CONCLUSIONS
The findings in this study demonstrate that the actual PSA in men receiving dutasteride would be multiplied by 2 considering the PSA regression rate after 12 months.

Keyword

5alpha-reductase inhibitor; Dutasteride; Prostate-specific antigen

MeSH Terms

Male
Humans

Figure

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  Fig. 1. Mean percent change from baseline in (A) prostate volume, (B) PSA, and (C) PSA density after dutasteride treatment during 12 months. PSA: prostate-specific antigen.

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  Fig. 2. (A) Prostate volume, (B) PSA, and (C) PSA density pattern according to the follow-up period after dutasteride treatment. PSA: †: 6 vs. 12 prostate-specific antigen. ∗: baseline vs. 6 months, months.

Reference

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