J Korean Med Sci.  2001 Jun;16(3):294-302. 10.3346/jkms.2001.16.3.294.

Viable myocardium in reperfused acute myocardial infarction: rest and stress first-pass mr imaging

• Chung KI
• Chung TS
• White RD
• Weinmann H
• Lim TH
• Choi BI
• Suh JH

• KMID: 1129900
• DOI: http://doi.org/10.3346/jkms.2001.16.3.294

Abstract

Feasibility of identifying viable myocardium in rest and stress magnetic resonance imaging (MRI) was evaluated using 3 hr occlusion and 30 min reperfusion model of left anterior descending (LAD) coronary artery in 12 felines. At rest MRI, viable myocardium confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC)- staining showed rapid signal intensity (SI) rise followed by gradual decline not significantly different from normal myocardium that the two hyperperfused regions were distinguishable only from the hypoperfused nonviable myocardium. At stress MRI, hyperemia induced perfusion change was most pronounced in normal myocardium with earlier and greater peak enhancement followed by brisk 'washout' phase while minimally augmented enhancement in viable myocardium was still in 'washin' phase. From these findings, it was concluded that viable myocardium is identified in rest and stress MRI as redistributing hypo- perfusion compared to persistent hyper-perfusion of the normal myocardium and the persistent hypo-perfusion of the nonviable myocardium.

Keyword

Perfusion Heart; Magnetic Resonance Spectroscopy; Myocardial Infarction; Myocardium; Myocardial Reperfusion; Image Enhancement

MeSH Terms

Animal
Cats
Heart/*radiography
Hyperemia/*radiography
Magnetic Resonance Imaging
Myocardial Infarction/*radiography
Myocardial Reperfusion Injury/*radiography
Stress