J Korean Med Sci.  2007 Aug;22(4):718-721. 10.3346/jkms.2007.22.4.718.

Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

• Lee SJ
• Hwang HS
• Kim BN
• Kim MA
• Lee JW
• Park YW
• Kim YH

• KMID: 1127093
• DOI: http://doi.org/10.3346/jkms.2007.22.4.718

Abstract

Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the changes in serum ADA activity throughout normal pregnancy. We measured the catalytic values of serum ADA from 202 normal pregnant women using a commercial kit. Subjects were divided into four groups according to the gestational age in weeks (Gwks) (Group I: 5-9 Gwks [n=58]; Group II: 15-20 Gwks [n= 63]; Group III: 24-30 Gwks [n=34]; Group IV: 30-39 Gwks [n=47]). The serum ADA levels for the Groups I, II, III, and IV were as follows: 20.1+/-6.9 IU/L, 20.0+/-7.6 IU/L, 37.9+/-19.9 IU/L, and 24.5+/-8.6 IU/L, respectively. The serum ADA activity of group III was significantly higher than the other groups (p<0.05). However, there was no significant correlation between the Gwks and the serum ADA activity. Furthermore, other parameters, such as maternal age (p=0.29), gestational age at delivery (p=0.07), delivery mode (p=0.39), and birth weight (p=0.59) had no correlation with ADA activity. Reference values of serum ADA in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered.

Keyword

Adenosine Deaminase; Immunity; Cellular; Pregnancy

MeSH Terms

Adenosine/metabolism
Adenosine Deaminase/*blood/*metabolism
Adult
Analysis of Variance
Birth Weight
Female
Gestational Age
Humans
Infant, Newborn
Inosine/metabolism
Logistic Models
Maternal Age
Pregnancy
Substrate Specificity

Figure

• 

  Fig. 1 Changes in serum ADA activity during normal pregnancies. *p<0.05 vs. Group I, II, and IV. Data represent median±standard error of median.

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