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Roles of Adenosine and Serotonin Receptors on the Antinociception of Sildenafil in the Spinal Cord of Rats

Lee HG, Kim WM, Park CH, Yoon MH

PURPOSE: The phosphodiesterase 5 inhibitor sildenafil has antinociceptive effects, mediated by an increase in cGMP. This study examined the role of spinal adenosine and serotonin receptors played in the antinociceptive...
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Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

Lee SJ, Hwang HS, Kim BN, Kim MA, Lee JW, Park YW, Kim YH

Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the...
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Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

Kim HS, Jeong SY, Lee JH, Kim BE, Kim JW, Jeong SW, Kim IK

  • KMID: 755099
  • Exp Mol Med.
  • 2000 Dec;32(4):197-203.
3-Deazaadenosine (DZA), one of the potent inhibitors of S-adenosylhomocysteine hydrolase, is known to possess several biological properties including an induction of apoptosis. To evaluate a possibility that DZA...
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