Clin Orthop Surg.  2009 Jun;1(2):90-95. 10.4055/cios.2009.1.2.90.

Contribution of the Proximal Nerve Stump in End-to-side Nerve Repair: In a Rat Model

  • 1Department of Orthopedic Surgery, Yeson Hospital, Bucheon, Korea.
  • 2Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea.


BACKGROUND: The aim of this study was to evaluate the contribution of the proximal nerve stump, in end-to-side nerve repair, to functional recovery, by modifying the classic end-to-side neurorrhaphy and suturing the proximal nerve stump to a donor nerve in a rat model of a severed median nerve.
Three experimental groups were studied: a modified end-to-side neurorrhaphy with suturing of the proximal nerve stump (double end-to-side neurorrhaphy, Group I), a classic end-to-side neurorrhaphy (Group II) and a control group without neurorrhaphy (Group III). Twenty weeks after surgery, grasping testing, muscle contractility testing, and histological studies were performed.
The grasping strength, muscle contraction force and nerve fiber count were significantly higher in group I than in group II, and there was no evidence of nerve recovery in group III.
The contribution from the proximal nerve stump in double end-to-side nerve repair might improve axonal sprouting from the donor nerve and help achieve a better functional recovery in an end-to-side coaptation model.


Median nerve; Proximal stump; Peripheral nerve injury; End-to-side neurorrhaphy; Nerve recovery
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