Yonsei Med J.  1988 Jun;29(2):160-165. 10.3349/ymj.1988.29.2.160.

Natural Killer Cell Activity in Rheumatoid Arthritis Measured by a Single Cell Cytotoxicity Assay

• Kim GS
• Youn JK
• Kim JD
• Kim NH

• KMID: 1119203
• DOI: http://doi.org/10.3349/ymj.1988.29.2.160

Abstract

The natural killer(NK) cell activity of mononuclear cells (MNC) from peripheral blood (PB) and synovial fluid (SF) of 40 rheumatoid arthritis(RA) patients was investigated by employing 51-chromium-(51Cr) release microcytotoxicity and single cell cytotoxicity assays against K562 target cells. It has been revealed that SF-MNC from RA patients showed a significantly lower NK activity than PB-MNC from the same patients and this might be due to an impaired target binding capacity of the effector cells and not due to a deficiency of active NK cells.

Keyword

Rheumatoid arthritis; NK cells; single cell cytotoxicity

MeSH Terms

Adolescent
Adult
Aged
Arthritis, Rheumatoid/*immunology
Chromium Radioisotopes/diagnostic use
Comparative Study
Cytotoxicity Tests, Immunologic/methods
*Cytotoxicity, Immunologic
Female
Human
In Vitro
Killer Cells, Natural/*immunology
Male
Middle Age
Support, Non-U.S. Gov't
Synovial Fluid/immunology