J Vet Sci.  2005 Jun;6(2):161-164.

Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats

• Bae JS
• Jang KH
• Jin HK

Abstract

Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus, Phellinus gilvus (PG) have various anti-inflammatory activities. In present study, we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours, each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete reepithelialization, as compared to wounds of non-treated (p < 0.05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings.

Keyword

diabetes; Phellinus gilvus; polysaccharides; rat; wound healing

MeSH Terms

Administration, Cutaneous
Animals
Anti-Inflammatory Agents/pharmacology
Basidiomycota/*metabolism
Diabetes Mellitus, Experimental/*pathology
Histocytochemistry
Male
Polysaccharides/isolation&purification/*pharmacology
Rats
Rats, Sprague-Dawley
Skin/*injuries
Streptozocin
Wound Healing/*drug effects
Wounds, Penetrating/*drug therapy