Korean J Intern Med.  2008 Dec;23(4):182-190. 10.3904/kjim.2008.23.4.182.

Autologous stem cell transplantation for diffuse large B-cell lymphoma with residual extranodal involvement

• Ko OB
• Jang G
• Kim S
• Huh J
• Suh C

• KMID: 1100766
• DOI: http://doi.org/10.3904/kjim.2008.23.4.182

Abstract

BACKGROUND/AIMS: Diffuse large B-cell lymphoma (DLBCL) in Koreans is frequently accompanied by extranodal (EN) disease at the time of autologous stem cell transplantation (ASCT). We sought to determine whether high EN involvement affected survival following ASCT in Koreans. METHODS: We reviewed 27 patients who had DLBCL with residual disease at ASCT: 13 with residual disease at nodal site(s) only and 14 with nodal and EN disease. RESULTS: Univariate analysis showed that disease status, lactate dehydrogenase (LDH), and performance status at ASCT were predictors of survival following ASCT. The number of EN sites, as categorized by the International Prognostic Index system, had no prognostic significance. When EN involvement at ASCT was classified as negative or positive, the 2-year overall survival for the negative group was 64%, significantly better than the 14% for the positive group (p=0.021), and the event-free survival for the negative group was 62%, significantly better than the 14% for the positive group (p=0.02). CONCLUSIONS: Patients who had DLBCL with residual EN involvement at ASCT showed worse outcomes following ASCT compared to those without EN disease.

Keyword

Diffuse large B-cell lymphoma; Autologous stem cell transplantation; Extranodal involvement; Residual disease

MeSH Terms

Adolescent
Adult
Aged
Cohort Studies
Female
Humans
Korea
Lymphoma, Large B-Cell, Diffuse/mortality/*pathology/*therapy
Male
Middle Aged
Neoplasm, Residual
Retrospective Studies
*Stem Cell Transplantation
Survival Rate
Treatment Outcome
Young Adult