Yonsei Med J.  1966 Dec;7(1):1-6. 10.3349/ymj.1966.7.1.1.

A Phase Contrast Microscopic Study on the Induction of Cellular Deformation in Mast Cells

• Choi KD
• Oh YK
• Park DU
• Rhim KS
• Cho TH

• KMID: 1094451
• DOI: http://doi.org/10.3349/ymj.1966.7.1.1

Abstract

The influence of colchicine, colcemid, ginseng-alcohol extract, saponin, garlic alcohol-ether extract, and X-irradiation on free floating peritoneal mast cells were studied in rats by means of a phase contrast microscope. After the intraperitoneal injection of colchicine or colcemid the mast cells of the albino rat peritoneal fluid show an altered morphology. Ginseng-alcohol extract, allicin extracted from garlic, and X-irradiation do not elicit this cytological response.Mast cells exposed to saponin exhibit a severe destruction and degranulation. The relation of the mast cell-damaging agents, metabolic poisons, and X1-irradiation to the mast cell response is discussed with reference to the morphological changes. These are compared with the data of Padawer (1960, 1966).

MeSH Terms

Animals
Colchicine/*pharmacology
Mast Cells/*drug effects/*radiation effects
Microscopy, Phase-Contrast
*Panax
Plant Extracts/pharmacology
*Plants, Medicinal
*Radiation Injuries, Experimental
Rats
Saponins/*pharmacology