J Korean Med Sci.  2011 Jul;26(7):900-905. 10.3346/jkms.2011.26.7.900.

Differential Relationship between Metabolic Syndrome Score and Severity of Coronary Atherosclerosis as Assessed by Angiography in a Non-Diabetic and Diabetic Korean Population

• Yoon SE
• Ahn SG
• Kim JY
• Park JS
• Shin JH
• Tahk SJ
• Lee SK
• Kim TJ
• Han N

• KMID: 1094261
• DOI: http://doi.org/10.3346/jkms.2011.26.7.900

Abstract

Whether the metabolic syndrome (MetS) has prognostic value for coronary artery disease (CAD) beyond its individual components is controversial. We compared the relationship between the number of MetS components and CAD severity as assessed by angiography in non-diabetic and diabetic subjects. We consecutively enrolled 527 patients who underwent their first coronary angiography. Patients were divided into four groups according to the number of MetS components: 0/1, 2, 3, and 4/5. A coronary atherosclerosis score was used to quantify the extent of atherosclerotic involvement. The relationship between the MetS score and angiographic CAD severity or clinical presentation was compared between non-diabetic and diabetic subjects. Individuals with the MetS (n = 327) had a higher prevalence of CAD (60% vs 32%, P < 0.001), multi-vessel disease (34% vs 16%, P < 0.001), and acute coronary syndromes (49% vs 26%, P < 0.001) than those without the MetS. In the non-diabetic group, atherosclerosis score increased with the MetS score (1.0 +/- 2.1, 2.0 +/- 2.9, 2.8 +/- 2.9, and 3.6 +/- 3.9, P < 0.001) whereas there was no significant difference in the diabetic group (0.5 +/- 1.0, 5.2 +/- 4.7, 4.2 +/- 2.9, and 4.4 +/- 3.5, P = 0.102). The MetS score is related to CAD severity in non-diabetic patients but the association between the MetS score and angiographic CAD severity may be obscured in the presence of diabetes.

Keyword

Metabolic Syndrome; Coronary Atherosclerosis; Coronary Angiography

MeSH Terms

Adult
Aged
*Coronary Angiography
Coronary Artery Disease/complications/*radiography
Diabetes Mellitus, Type 2/*complications
Female
Humans
Male
Metabolic Syndrome X/*complications/diagnosis
Middle Aged
Odds Ratio
Prognosis
Republic of Korea
Risk Factors
*Severity of Illness Index

Figure

• 

  Fig. 1 Coronary atherosclerosis score according to the presence of the metabolic syndrome (MetS) or diabetes mellitus (DM). *vs MetS(+)DM(-), MetS(+)DM(+), P < 0.001, vs MetS(-)DM(+), P = 0.035; †vs MetS(+)DM(+), P = 0.002.

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