J Vet Sci.
2005 Dec;6(4):357-359.
Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice
- Affiliations
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- 1Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea. ischoi@konkuk.ac.kr
- 2Institute of Biomedical Science and Technology, Konkuk University, Seoul 143-701, Korea.
- 3Foreign Animal Disease Division, National Veterinary Research and Quarantine Service, Anyang 430-016, Korea.
- 4Department of Animal Sciences and Environment, College of Animal Husbandry, Konkuk University, Seoul 143-701, Korea.
Abstract
- Proliferative enteropathy was reproduced in IFN-gamma receptor knockout (IFN-gamma R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-gamma were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-gamma produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.
MeSH Terms
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Animals
DNA, Viral
Desulfovibrionaceae Infections/*immunology/microbiology
Interferon Type II/*immunology
Intestinal Diseases/*immunology/microbiology
Intestinal Mucosa/immunology
Lawsonia Bacteria/*immunology/isolation&purification
Mice
Mice, Knockout
Polymerase Chain Reaction
Receptors, Interferon/physiology
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