J Vet Sci.  2009 Mar;10(1):81-83. 10.4142/jvs.2009.10.1.81.

Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog

• Psychas V
• Loukopoulos P
• Polizopoulou ZS
• Sofianidis G

• KMID: 1089351
• DOI: http://doi.org/10.4142/jvs.2009.10.1.81

Abstract

Multilobular tumour of bone (MTB) is an uncommon tumour and is usually located in the skull. A 13-year-old mixed breed dog was presented with a two-week history of progressively worsening vestibular dysfunction and cognitive abnormalities; it appeared demented and showed asymmetric ataxia and hypermetria of all limbs. The owner opted to have the animal euthanised. Necropsy revealed a large mass occupying the right occipital, parietal and temporal bones, severely compressing the cerebellum and the right occipital lobe. Histologically, it was characterised by the presence of multiple lobules containing osteoid or cartilage and separated by fibrous septae, features typical of MTB. Lung metastases were evident. To our knowledge, this is the first report of an MTB causing both severe cerebral and cerebellar compression and the second detailed report of an MTB of the occipital bone. MTB should be included in the differential diagnosis of bone tumours as well as in cases with central vestibular disease.

Keyword

dog; metastases; multilobular tumour; osseous neoplasms; skull

MeSH Terms

Animals
Dog Diseases/*diagnosis/pathology
Dogs
Male
Skull/*pathology
Skull Neoplasms/diagnosis/pathology/*veterinary

Figure

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  Fig. 1 Note the presence of a large, spherical, whitish to yellow, well-circumscribed mass occupying the right occipital, parietal and temporal bones (A, B) and protruding from the right occipital bone (A). The mass expanded into the cranial cavity (B) and severely compressed the cerebellum and the right occipital lobe (encircled C and D before and after the removal of the meninges, respectively).

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  Fig. 2 Primary (A, B, C) and secondary (D) multilobular tumour of bone. Note the dominant presence of multiple lobules containing osteoid tissue (C: left) or cartilage (C: right) and separated by fibrous septa, a feature typical of the multilobular tumour of bone. In marginal areas (C), the lobules were not as well formed and the tumour cells were in places arranged in sheets, features denoting a high-grade malignancy. (D) Metastatic focus in the lungs retaining the multilobular pattern, albeit forming lobules that were smaller and of more uniform size. H&E stain, (A) decalcified section. Scale bars = A: 260 µm, B: 104 µm, C: 52 µm, D: 260 µm.

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