Korean J Radiol.  2009 Apr;10(2):194-196. 10.3348/kjr.2009.10.2.194.

A False Positive 18F-FDG PET/CT Scan Caused by Breast Silicone Injection

Affiliations
  • 1Department of Nuclear Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan. ntchiu@mail.ncku.edu.tw
  • 2Department of Pathology, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.

Abstract

We present here the case of a 40-year-old woman with a greater than 10 year prior history of bilateral breast silicone injection and saline bag implantation. Bilateral palpable breast nodules were observed, but the ultrasound scan was suboptimal and the magnetic resonance imaging showed no gadolinium-enhanced tumor. The 18F-FDG PET/CT scan showed a hypermetabolic nodule in the left breast with a 30% increase of 18F-FDG uptake on the delayed imaging, and this mimicked breast cancer. She underwent a left partial mastectomy and the pathology demonstrated a siliconoma.

Keyword

Breast, siliconoma; 18F-FDG PET/CT

MeSH Terms

Adult
Breast Implants/adverse effects
Breast Neoplasms/diagnosis
Diagnosis, Differential
*False Positive Reactions
Female
Fluorodeoxyglucose F18/diagnostic use
Granuloma, Foreign-Body/*diagnosis
Humans
Injections
*Positron-Emission Tomography
Radiopharmaceuticals/diagnostic use
Silicones/administration & dosage/*adverse effects
*Tomography, X-Ray Computed

Figure

  • Fig. 1 False positive FDG PET/CT caused by breast silicone injection in 40-year-old female.


Reference

1. Leibman AJ, Sybers R. Mammographic and sonographic findings after silicone injection. Ann Plast Surg. 1994. 33:412–414.
2. Cheung YC, Su MY, Ng SH, Lee KF, Chen SC, Lo YF. Lumpy silicone-injected breasts: enhanced MRI and microscopic correlation. Clin Imaging. 2002. 26:397–404.
3. Noh DY, Yun IJ, Kang HS, Kim YC, Kim JS, Chung JK, et al. Detection of cancer in augmented breasts by positron emission tomography. Eur J Surg. 1999. 165:847–851.
4. Wahl RL, Helvie MA, Chang AE, Andersson I. Detection of breast cancer in women after augmentation mammoplasty using fluorine-18-fluorodeoxyglucose-PET. J Nucl Med. 1994. 35:872–875.
5. Bhargava P, Glass E, Ghesani M. Inflammatory F-18 FDG uptake secondary to ruptured breast prosthesis. Clin Nucl Med. 2006. 31:227–228.
6. Hurwitz R. F-18 FDG positron emission tomographic imaging in a case of ruptured breast implant: inflammation or recurrent tumor? Clin Nucl Med. 2003. 28:755–756.
7. Kumar R, Loving VA, Chauhan A, Zhuang H, Mitchell S, Alavi A. Potential of dual-time-point imaging to improve breast cancer diagnosis with 18F-FDG PET. J Nucl Med. 2005. 46:1819–1824.
8. Ichiya Y, Kuwabara Y, Sasaki M, Yoshida T, Akashi Y, Murayama S, et al. FDG-PET in infectious lesions: the detection and assessment of lesion activity. Ann Nucl Med. 1996. 10:185–191.
9. Mochizuki T, Tsukamoto E, Kuge Y, Kanegae K, Zhao S, Hikosaka K, et al. FDG uptake and glucose transporter subtype expressions in experimental tumor and inflammation models. J Nucl Med. 2001. 42:1551–1555.
10. Mamede M, Higashi T, Kitaichi M, Ishizu K, Ishimori T, Nakamoto Y, et al. [18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung. Neoplasia. 2005. 7:369–379.
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