Korean J Radiol.  2009 Apr;10(2):190-193. 10.3348/kjr.2009.10.2.190.

Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus

• Kim GJ
• Lee ES

• KMID: 1088731
• DOI: http://doi.org/10.3348/kjr.2009.10.2.190

Abstract

We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28(+3) weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly with cerebral ventriculomegaly, although not specific, may be a suggestive finding of Down syndrome with transient abnormal myelopoiesis. Prompt fetal blood sampling for liver function test and chromosomal analysis are mandatory for early detection and management.

Keyword

Transient abnormal myelopoiesis; Hepatosplenomegaly; Ventriculomegaly; Down syndrome

MeSH Terms

Adult
Down Syndrome/*ultrasonography
Female
Fetal Blood/cytology
Fetal Death
Fetal Diseases/*diagnosis
Hepatomegaly/ultrasonography
Humans
Leukocytosis/diagnosis
*Myelopoiesis
Pregnancy
*Prenatal Diagnosis
Splenomegaly/ultrasonography
Thrombocytopenia/diagnosis