Exp Mol Med.
2009 Apr;41(4):253-258. 10.3858/emm.2009.41.4.028.
Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria
- Affiliations
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- 1Division of Nephrology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 2ILCHUN Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea. jeongsun@snu.ac.kr
- 3Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea.
- 4PSOMA Therapeutics Inc., Seoul, Korea.
- 5Macrogen Inc., Seoul, Korea.
- KMID: 1088600
- DOI: http://doi.org/10.3858/emm.2009.41.4.028
Abstract
- It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondrial DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
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