Korean J Ophthalmol.  2008 Sep;22(3):194-196. 10.3341/kjo.2008.22.3.194.

Photodynamic Therapy Treatment for Eyes with Drusenoid Pigment Epithelium Detachment

• Lee NY
• Kim KS

• KMID: 1070758
• DOI: http://doi.org/10.3341/kjo.2008.22.3.194

Abstract

We report the clinical course of photodynamic therapy (PDT) in a patient with drusenoid pigment epithelium detachment (PED). A patient with drusenoid PED underwent PDT follow-up was carried out at one week, one month, three months, six months and one year after treatment. Fundus exam, optical coherence tomography (OCT) and fluorescein angiography were performed. After the PDT, drusen and PED were gradually diminished over one year. However, pure serous PED eventually developed at the same location of the drusenoid PED. The results of the PDT, on drusenoid PED, were initially effective, but not completely successful. Therefore, PDT may be considered as an alternative treatment option for drusenoid PED.

Keyword

Drusenoid pigment epithelium detachment; Photodynamic therapy

MeSH Terms

Aged
Fluorescein Angiography
Humans
Male
*Photochemotherapy
Photosensitizing Agents/*therapeutic use
Pigment Epithelium of Eye/*drug effects/pathology
Porphyrins/*therapeutic use
Retinal Detachment/diagnosis/*drug therapy
Retinal Drusen/diagnosis/*drug therapy
Tomography, Optical Coherence

Figure

• 

  Fig. 1 (A, B, C) Fundus photography and optical coherence tomography (OCT) at the first examination showed multiple pigment epithelium detachments. Fluorescein angiography revealed delayed, regular hyperfluorescence without leakage. There was no evidence of choroidal neovascularization (CNV). (D, E, F) Ten months after photodynamic therapy (PDT), fundus photography, OCT and ICG showed that the drusenoid PED diminished in size.

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  Fig. 2 (A) Fifteen days after PDT, there was no interval change, on the fundus examination. (B) Five months after PDT, the fundus examination showed a decreased size of the soft drusen. (C) Ten months after PDT, the corrected vision of the left eye was improved to 20/25. On fundus examination, the number of soft drusen was markedly decreased.

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