J Korean Med Sci.  2001 Feb;16(1):9-14. 10.3346/jkms.2001.16.1.9.

Transplacental transfer and age-related levels of serum IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae types 14 and 19 in Korea

• Yoon JK
• Lee HH
• Choi BM
• Kim KB
• Park HY
• Lim JY
• Choung JT
• Tockgo YC

• KMID: 1066487
• DOI: http://doi.org/10.3346/jkms.2001.16.1.9

Abstract

Little is known about the prevalence of naturally acquired IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae (pneumococcal IgG) in Korea. In the present study, we investigated transplacental transfer and age-related levels of pneumococcal IgG to provide background seroepidemiologic data for S. pneumoniae in Korea. One hundred thirty eight sera were assayed by ELISA for IgG to pneumococcal polysaccharide capsular serotypes 14 and 19, the predominant serotypes for under 15 yr of age in Korea. The subjects were divided into 7 subgroups according to age. The cord/maternal geometric mean titer of pneumococcal were 4.47+/-5.88/5.21 +/- 5.88 for serotype 14, and 4.68 +/- 5.55/6.55 +/- 6.92 for serotype 1 9 (mean +/- standard deviation, microg/mL). After birth, the geometric mean titers of pneumococcal IgG for serotypes 14 and 19 expressed in microg/mL were 1.18+/-2.12 and 1.41+/-2.17 in the 0-6 months group, 0.27+/-0.19 and 0.69+/-0.93 in 7-12 months, 0.21+/-0.22 and 0.64+/-1.32 in 1-2 yr, 0.69+/-0.78 and 2.65+/-2.46 in 3-6 yr, 2.52+/-2.72 and 8.29+/-4.24 in 7-10 yr, respectively. In conclusion, reduced transplacental transfer and very low serum concentrations of pneumococcal IgG may contribute to the susceptibility of neonates, infants, and young children to S. pneumoniae infection.

Keyword

IgG; Streptococcus pneumoniae; Polysaccharides; Enzyme-Linked Immunosorbent Assay

MeSH Terms

Age Factors
Antibodies, Bacterial/metabolism*
Bacterial Capsules/immunology*
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Human
IgG/metabolism*
IgG/blood
Infant
Infant, Newborn
Male
Maternal-Fetal Exchange*
Pneumococcal Vaccines/immunology
Pregnancy
Streptococcus pneumoniae/immunology*
Vaccines, Conjugate/immunology