Exp Mol Med.  2007 Jun;39(3):327-334.

Association between angiotensin-1 converting enzyme gene olymorphism and the metabolic syndrome in a Mexican opulation

• Alvarez-Aguilar C
• Enriquez-Ramirez ML
• Figueroa-Nunez B
• Gomez-Garcia A
• Rodriguez-Ayala E
• Moran-Moguel C
• Farias-Rodriguez VM
• Mino-Leon
• Lopez-Meza JE

Abstract

Metabolic Syndrome (MS) is recognized as a cluster of cardiovascular risk factors. All components of MS have a genetic base. Genes of the renin angiotensin system are potential candidate genes for MS. We investigated whether angiotensin converting enzyme (ACE) gene polymorphism increases susceptibility to MS as an entity in a Mexican population. In a cross-sectional study, 514 individuals were studied including 245 patients with MS and 269 subjects without MS criteria. ACE gene polymorphism was detected using PCR. MS was defined according to The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) criteria, except that the raised fasting plasma glucose >or=100 mg/dl criterion for identification of intolerance fasting glucose was modified in accordance with the suggestion of the American Diabetes Association. Patients with MS were significantly different from subjects without MS in relation to mean body mass index (BMI), waist circumference (WC), systolic blood pressure, diastolic blood pressure, glucose, total cholesterol (C), triglycerides, HDL-C, and LDL-C (P<0.0001). The differences in the mean BMI, WC, glucose, total cholesterol, triglycerides, LDL-C, and HDL-C were maintained in patients with the MS and DD genotypes (P<0.01). The DD genotype was strongly associated with MS (adjusted OR=5.48, 95% CI 3.20-9.38, P<0.0001). We concluded that the DD genotype increases susceptibility to MS in a Mexican population. These results indicate that pharmacological and non-pharmacological treatment and a reduction in body fat will have important therapeutic implications in this disease.

Keyword

metabolic syndrome X; obesity; peptidyl-dipeptidase A; polymorphism, genetic; renin-angiotensin system; risk factors

MeSH Terms

Aged
Cross-Sectional Studies
Female
*Genetic Predisposition to Disease
Humans
Male
Metabolic Syndrome X/*genetics
Mexico
Middle Aged
Peptidyl-Dipeptidase A/*genetics
*Polymorphism, Genetic
Population Groups/genetics
Risk Factors