Exp Mol Med.
2007 Jun;39(3):304-315.
Effects of retinoic acid on ischemic brain injury-induced eurogenesis
- Affiliations
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- 1Department of Neurology, School of Medicine, Pusan National University, Busan 602-739, Korea.
- 2Department of Anatomy, School of Medicine, Pusan National University, Busan 602-739, Korea. hedgehog@pusan.ac.kr
- 3Department of Psychiatry, School of Medicine, Pusan National University, Busan 602-739, Korea.
- 4Department of Radiology, School of Medicine, Pusan National University, Busan 602-739, Korea.
- 5Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Busan 602-739, Korea.
Abstract
- Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
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