Korean J Parasitol.  1992 Jun;30(2):125-131. 10.3347/kjp.1992.30.2.125.

Changes in blastogenic responses and antibody titers of mice infected with Toxoplasma gondii

• Shin DW
• Lee YH
• Na YE
• Kwon DS

• KMID: 1044814
• DOI: http://doi.org/10.3347/kjp.1992.30.2.125

Abstract

This study was performed to observe the cell-mediated and humoral immune responses in mice which were infected with Beverley, Fukaya and ME49 strain of Toxoplasma gondii, respectively. The blastogenic responses of splenocytes using [3H]-thymidine and serum antibody titers were measured weekly up to 10 weeks after infection. The blastogenic responses of splenocytes treated with concanavalin A and Toxoplasma lysate were significantly declined in the 3 strain groups as compared with the non-infected group (p less than 0.05), however lipopolysaccharide-treated blastogenic responses were not significantly different between infected and non-infected groups. The serum IgG antibody titers in the three infected groups increased from 2 weeks after infection, and the serum IgM antibody titers increased until 4 weeks after infection. No significant differences were revealed in blastogenic responses and serum antibody titers among the 3 groups. The present study suggested that cell-mediated immune responses were involved in T. gondii infected mice and blastogenic responses of T lymphocytes were inhibited in acute T. gondii infection.

MeSH Terms

English-Abstract
IgG-biosynthesis
IgM-biosynthesis
Immunity,-Cellular
Lymphocyte-Transformation
Mice-
Mice,-Inbred-BALB-C
*Antibodies,-Protozoan-biosynthesis
*Toxoplasma-immunology
*Toxoplasmosis,-Animal-immunology
Antibodies,-Protozoan
IgG
IgM